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J Gastroen Hepatol：丙型肝炎直接抗病毒疗法效果比较

2017-07-08 zhangfan MedSci原创

HCVSVR肝硬化
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3种直接抗病毒药物均表现出较高的持续病毒学应答率

丙型肝炎感染患者服用直接抗病毒药物的真实效果如何？近日研究人员利用队伍军人健康管理数据比较了三种药物治疗方案的12周持续病毒学应答率。这项回顾性队列研究数据采集截至2015年7月1日，数据从退伍军人健康管理局的电子病历系统检索获取。采用意向治疗法和逻辑回归分析比较药物治疗方案持续病毒学应答率的差异。研究共收集了11464名患者资料。在调整其他风险因素后，各治疗方案的12周的持续病毒应答率如下：ledipasvir+sofosbuvir，92%；ombitasvir+paritaprevir+ritonavir+dasabuvir，86%；simeprevir+sofosbuvir，83%。在对于患者疾病特征进行调整后，， simeprevir+sofosbuvir 的持续病毒应答为93.3%而ledipasvir+sofosbuvir 为96.2%，高于ombitasvir+paritaprevir+ritonavir+dasabuvir 的91.8%。人类免疫缺陷病毒、乙型肝炎病毒感染、糖尿病、肥胖、既往治疗史及使用利巴韦林强化治疗不影响持续病毒学应答率，但65岁以上，肝硬化，代偿失

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    2017-09-16 ms24272190615788285182

    #AST#

    0

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    2017-11-02 许安

    #GAS#

    0

  3. 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    2017-10-17 仁者大医

    #直接抗病毒#

    0

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GetPortalCommentsPageByObjectIdResponse(id=220072, encodeId=4ff72200e20b, content=彻底治愈了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jul 08 22:10:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 吴教授

    学习了，学习了

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=220072, encodeId=4ff72200e20b, content=彻底治愈了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jul 08 22:10:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 zjubiostat

    #丙型肝炎#

    0

  6. 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    2017-07-10 yahu

    #抗病毒#

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=220072, encodeId=4ff72200e20b, content=彻底治愈了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jul 08 22:10:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 gwc384

    #EPA#

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=220072, encodeId=4ff72200e20b, content=彻底治愈了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jul 08 22:10:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 Eleven15

    #抗病毒疗法#

    0

  9. 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    2017-07-09 明月清辉

    谢谢分享，学习了

    0

  10. 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    2017-07-08 lovetcm

    彻底治愈了

    0

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