SCI REP:乙型肝炎和丙型肝炎病毒感染与糖尿病有何关系?

2017-07-04 xing.T MedSci原创

在这个糖尿病风险较低的大型人群中,HBV和HCV感染与糖尿病患病率相关,并且HBV感染与糖尿病的发生风险相关。该研究增加了证据表明糖尿病是HBV和HCV感染的一个额外代谢并发症。

肝炎病毒感染在葡萄糖稳态中的作用还不确定。近日,Scientific reports 杂志上发表了一篇研究文章,研究人员在一个无症状健康体检参与者的队列(n=439708)中评估了乙型肝炎病毒(HBV)或丙型肝炎病毒(HCV)感染糖尿病发生发展之间的相关性。

在横断面分析中,多变量调整后,研究人员发现乙型肝炎表面抗原(HBsAg)(+)的患者与HBsAg(−)的患者相比,患糖尿病的比值比为1.17(95%可信区间为1.06-1.31;P=0.003)。相应的丙型肝炎抗体(抗-HCV)(+)的患者与丙型肝炎病毒抗体(−)的患者相比,患糖尿病的比值比为1.43(95%可信区间为1.01-2.02,P=0.043)。

在前瞻性分析中,多变量调整后HBsAg(+)患者与HbsAg(−)患者相比患糖尿病的风险比为1.23(95%可信区间为1.08-1.41;P=0.007)。在丙型肝炎病毒(+)的参与者(10例)中发生糖尿病的病例数太小,以致无法可靠地估计HCV感染与糖尿病之间的潜在的相关性。

在这个糖尿病风险较低的大型人群中,HBV和HCV感染与糖尿病患病率相关,并且HBV感染与糖尿病的发生风险相关。该研究增加了证据表明糖尿病是HBV和HCV感染的一个额外代谢并发症。

原始出处:

Yun Soo Hong,et al. Hepatitis B and C virus infection and diabetes mellitus: A cohort study.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04206-6

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    2017-07-09 杨利洪

    学习了分享了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1825614, encodeId=592f1825614bb, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Mon Apr 23 05:07:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220183, encodeId=fa5a2201833d, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Sun Jul 09 07:12:19 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219843, encodeId=109821984336, content=好文章学习了谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 08 08:50:19 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274588, encodeId=8cb412e4588d8, content=<a href='/topic/show?id=30872089e03' target=_blank style='color:#2F92EE;'>#丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20897, encryptionId=30872089e03, topicName=丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Thu Jul 06 10:07:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429538, encodeId=1c99142953894, content=<a href='/topic/show?id=534e2090181' target=_blank style='color:#2F92EE;'>#丙型肝炎病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20901, encryptionId=534e2090181, topicName=丙型肝炎病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a26a4213133, createdName=anan, createdTime=Thu Jul 06 10:07:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218907, encodeId=2b2121890e41, content=糖尿病是HBV和HCV感染的一个额外代谢并发症。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Wed Jul 05 19:56:15 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218657, encodeId=970f21865eac, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Wed Jul 05 05:56:32 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218581, encodeId=4c79218581a2, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Tue Jul 04 20:06:19 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218575, encodeId=68412185e5bf, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Jul 04 19:59:17 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-08 大爰

    好文章学习了谢谢!

    0

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    2017-07-05 ren1mw

    糖尿病是HBV和HCV感染的一个额外代谢并发症。

    0

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    2017-07-05 152****8376

    谢谢分享受益匪浅

    0

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    2017-07-04 王秀

    学习了,涨知识了!

    0

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    2017-07-04 changjiu

    学习了,谢谢

    0

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