SCI REP:非酒精性脂肪肝与冠状动脉钙化有何关系?

2017-08-30 xing.T MedSci原创

由此可见,该研究的发现进一步证实了NAFLD与CAC之间存在的关联,特别是在亚洲人群中。

非酒精性脂肪肝(NAFLD)已成为一个新兴的健康问题,在一般人群中发病率很高。近日,Scientific reports 杂志上发表了一篇研究文章,在这个横断面研究中,研究人员通过分析中国北方城市居民探讨了NAFLD与冠状动脉钙化(CAC)之间的关联。

该研究共有2345名年龄≥40岁(1035名男性和1310名女性)选自于唐山市鸡东社区的参与者。研究人员通过肝脏超声检查来诊断NAFLD。64层螺旋CT扫描被用于测定冠状动脉钙化积分(CACS),CACS>0定义为存在CAC。冠状动脉粥样硬化性心脏病(CHD)的风险水平根据在临床实践中常用的CACS4种阈值来进行分级(0、10、100和400Agatston单位)。

研究人员发现NAFLD与CAC显著相关(粗略OR为1.631,95%CI为1.295-2.053,调整后的OR为1.348,95%CI为1.030-1.765)。研究人员也观察到了非酒精性脂肪性肝病与冠心病风险增加之间存在相关性(粗略OR为1.639,95%CI为1.303-2.063;调整后的OR为1.359,95%CI为1.043-1.770)。在女性中,非酒精性脂肪肝与CAC或冠心病风险增加之间具有显著性差异,但在男性中并无显著性差异。

由此可见,该研究的发现进一步证实了NAFLD与CAC之间存在的关联,特别是在亚洲人群中。

原始出处:


Rina Wu,et al. Nonalcoholic Fatty Liver Disease and Coronary Artery Calcification in a Northern Chinese Population: a Cross Sectional Study.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-09851-5

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  5. 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  6. 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    2017-09-15 虈亣靌

    未来的发展前景广阔

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=239505, encodeId=b69d239505f8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat Sep 02 00:13:34 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269192, encodeId=ee73126919229, content=<a href='/topic/show?id=686830913f7' target=_blank style='color:#2F92EE;'>#冠状动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30913, encryptionId=686830913f7, topicName=冠状动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Fri Sep 01 10:08:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239167, encodeId=f06f23916e9b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Sep 01 05:34:32 CST 2017, time=2017-09-01, status=1, ipAttribution=)]
    2017-09-02 虈亣靌

    好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Sep 15 20:45:34 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239736, encodeId=e8c4239e36d0, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Sep 02 13:43:55 CST 2017, time=2017-09-02, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=239167, encodeId=f06f23916e9b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Sep 01 05:34:32 CST 2017, time=2017-09-01, status=1, ipAttribution=)]
    2017-09-02 yfjms

    学习了

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Sep 15 20:45:34 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239736, encodeId=e8c4239e36d0, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Sep 02 13:43:55 CST 2017, time=2017-09-02, status=1, ipAttribution=), 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  10. 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objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Sep 15 20:45:34 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239736, encodeId=e8c4239e36d0, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Sep 02 13:43:55 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239505, encodeId=b69d239505f8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat Sep 02 00:13:34 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269192, encodeId=ee73126919229, content=<a href='/topic/show?id=686830913f7' target=_blank style='color:#2F92EE;'>#冠状动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30913, encryptionId=686830913f7, topicName=冠状动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Fri Sep 01 10:08:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239167, encodeId=f06f23916e9b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Sep 01 05:34:32 CST 2017, time=2017-09-01, status=1, ipAttribution=)]
    2017-09-01 一个字-牛

    学习了谢谢分享

    0

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由此可见,血浆DPP4活性与NAFLD密切相关。其机制可能部分归因于胰岛素抵抗、氧化应激、炎症和DPP4之间的相互作用。

Hepatology:非酒精性脂肪性肝病流行率模型预测疾病负担呈指数形式递增

非酒精性脂肪性肝病(NAFLD)和由NAFLD导致的非酒精性脂肪性肝炎(NASH)在美国高度流行,导致肝硬化和肝细胞癌发病不断增加,逐渐成为肝移植手术指征。本研究采用马尔科夫模型预测NAFLD疾病进展。

Hepatology:肥胖、胰岛素抵抗等因素对非酒精性脂肪肝病患者血浆氨基酸含量的影响

非酒精性脂肪性肝病(NAFLD)患者经常被发现血浆氨基酸含量,特别是支链氨基酸含量增高。然而,氨基酸含量的增高是否由于肌肉蛋白分解代谢增加,肥胖或胰岛素抵抗增加或组织代谢受损等原因,目前还未知。

Hepatology:肝纤维化分期而非非酒精性脂肪性肝炎可预测患者死亡率和发展为严重肝病的时间

在平均20年的随访中(范围:0-40),相当于13163人年,12%的NAFLD患者和2.2%的正常对照发展为严重肝病(p<0.001)。相比正常对照,严重肝病的风险随着肝纤维化分期的增加而增高。

Metabolism:咖啡摄入量与非酒精性脂肪肝患者的亚临床CVD或CVD事件风险无关!

在一个大规模的基于人群的队列中,咖啡摄入量与亚临床心血管病的患病率没有关系,咖啡也不会影响未来的心血管事件的风险,无论潜在的NAFLD状态如何。

Liver Int:脂肪变性影响非酒精性脂肪性肝病非侵袭性纤维化诊断结果

脂肪变性程度可能影响NAFLD患者非侵入性肝纤维化检测的诊断性能。为了优化非侵袭性纤维化评估性能,应为不同的NAFLD亚组患者定制不同的个性化应用。