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ESH 2016：甜菜根汁对动脉功能和心脏结构的影响

2016-07-05 Seven L 译 MedSci原创

甜菜根汁动脉硬度心脏
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2016年欧洲高血压学会(ESH)年会上，来自伦敦大学国王学院的两项研究表明，虽然螺内酯和/或硝酸盐饮食不能改善2型糖尿病患者的动脉硬度，但能影响患者的心脏重构和左室收缩舒张功能。第一项试验纳入了126名年龄在18岁-90岁（平均年龄57.3岁，64%为男性）的2型糖尿病或高危患者。予以不同的干预，探究甜菜根汁中的硝酸盐能否低患者的动脉硬度（独立于血压因素）。使用VaSera(Fukuda-Den

2016年欧洲高血压学会(ESH)年会上，来自伦敦大学国王学院的两项研究表明，虽然螺内酯和/或硝酸盐饮食不能改善2型糖尿病患者的动脉硬度，但能影响患者的心脏重构和左室收缩舒张功能。

第一项试验纳入了126名年龄在18岁-90岁（平均年龄57.3岁，64%为男性）的2型糖尿病或高危患者。予以不同的干预，探究甜菜根汁中的硝酸盐能否低患者的动脉硬度（独立于血压因素）。使用VaSera(Fukuda-Denshi)测量心-踝血管指数(CAVI)作为评估指标。最终分析了104名患者的数据。

数据显示，治疗24周后，25-50 mg/天 螺内酯组 vs.8-16 mg/天 多沙唑嗪组、4.5-9 mmol硝酸盐甜菜根汁组 vs.不含硝酸盐的甜菜根汁组，主要终点CAVI无显著性差异。

但是多沙唑嗪组 vs.螺内酯组，动脉脉搏波传导速度（PWV）显著下降(P<0.05)；不过含或不含硝酸盐的甜菜根汁组间PWV无显著差异。

第二项试验纳入了113名患者，最终92名患者完成了6个月随访。

数据显示，治疗6个月后，螺内酯 vs.多沙唑嗪组，相对室壁厚度、左室质量指数和E/A比值等相比基线有下降。含硝酸盐甜菜根汁组 vs.不含硝酸盐的甜菜根汁组，质量/体积比增加、收缩末期和舒张末期容积下降。

研究期间没有发现严重的副作用。不过J Kennedy Cruickshank博士作为两项研究的主要研究人员，他指出，所有参与者都超重，这是不容忽视的。

全球最大的死因是心血管疾病，如果在以后能有更多的饮食和心血管健康的研究，并看到成效、付诸实践，那么在以后社会的健康负担将大大下降。

原始出处：

Mixed Results for Beet-Juice Effects on Arterial Function, Heart Structure.Medscape.June 22, 2016

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  1. [GetPortalCommentsPageByObjectIdResponse(id=122105, encodeId=c69d1221055e, content=己拜读，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 08:59:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105745, encodeId=262b105e4560, content=好文，值得学习，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 17:00:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798329, encodeId=016f1e98329cc, content=<a href='/topic/show?id=73d56885904' target=_blank style='color:#2F92EE;'>#甜菜根#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68859, encryptionId=73d56885904, topicName=甜菜根)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Aug 12 12:30:00 CST 2016, time=2016-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522095, encodeId=26a715220952f, content=<a href='/topic/show?id=7989e00931' target=_blank style='color:#2F92EE;'>#ESH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7009, encryptionId=7989e00931, topicName=ESH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=877111409735, createdName=wfang549, createdTime=Thu Jul 07 04:30:00 CST 2016, time=2016-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616002, encodeId=7fb11616002d2, content=<a href='/topic/show?id=120f516469e' target=_blank style='color:#2F92EE;'>#心脏结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51646, encryptionId=120f516469e, topicName=心脏结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41019719888, createdName=12498adam46暂无昵称, createdTime=Thu Jul 07 04:30:00 CST 2016, time=2016-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92003, encodeId=92bf92003b2, content=好文章，学习学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Tue Jul 05 16:42:00 CST 2016, time=2016-07-05, status=1, ipAttribution=)]
    2016-09-11 1e10c84am36(暂无匿称)

    己拜读，受益匪浅

    0

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    2016-08-27 ylzr123

    好文，值得学习，赞一个。

    0

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    2016-08-12 Boyinsh

    #甜菜根#

    0

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    2016-07-07 wfang549

    #ESH#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=122105, encodeId=c69d1221055e, content=己拜读，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 08:59:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105745, encodeId=262b105e4560, content=好文，值得学习，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 17:00:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798329, encodeId=016f1e98329cc, content=<a href='/topic/show?id=73d56885904' target=_blank style='color:#2F92EE;'>#甜菜根#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68859, encryptionId=73d56885904, topicName=甜菜根)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Aug 12 12:30:00 CST 2016, time=2016-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522095, encodeId=26a715220952f, content=<a href='/topic/show?id=7989e00931' target=_blank style='color:#2F92EE;'>#ESH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7009, encryptionId=7989e00931, topicName=ESH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=877111409735, createdName=wfang549, createdTime=Thu Jul 07 04:30:00 CST 2016, time=2016-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616002, encodeId=7fb11616002d2, content=<a href='/topic/show?id=120f516469e' target=_blank style='color:#2F92EE;'>#心脏结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51646, encryptionId=120f516469e, topicName=心脏结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41019719888, createdName=12498adam46暂无昵称, createdTime=Thu Jul 07 04:30:00 CST 2016, time=2016-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92003, encodeId=92bf92003b2, content=好文章，学习学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Tue Jul 05 16:42:00 CST 2016, time=2016-07-05, status=1, ipAttribution=)]
    2016-07-07 12498adam46暂无昵称

    #心脏结构#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=122105, encodeId=c69d1221055e, content=己拜读，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 08:59:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105745, encodeId=262b105e4560, content=好文，值得学习，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 17:00:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798329, encodeId=016f1e98329cc, content=<a href='/topic/show?id=73d56885904' target=_blank style='color:#2F92EE;'>#甜菜根#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68859, encryptionId=73d56885904, topicName=甜菜根)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Aug 12 12:30:00 CST 2016, time=2016-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522095, encodeId=26a715220952f, content=<a href='/topic/show?id=7989e00931' target=_blank style='color:#2F92EE;'>#ESH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7009, encryptionId=7989e00931, topicName=ESH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=877111409735, createdName=wfang549, createdTime=Thu Jul 07 04:30:00 CST 2016, time=2016-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616002, encodeId=7fb11616002d2, content=<a href='/topic/show?id=120f516469e' target=_blank style='color:#2F92EE;'>#心脏结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51646, encryptionId=120f516469e, topicName=心脏结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41019719888, createdName=12498adam46暂无昵称, createdTime=Thu Jul 07 04:30:00 CST 2016, time=2016-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92003, encodeId=92bf92003b2, content=好文章，学习学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Tue Jul 05 16:42:00 CST 2016, time=2016-07-05, status=1, ipAttribution=)]
    2016-07-05 jaysppr

    好文章，学习学习！

    0