Semin Arthritis Rheu:遗传性血色病与关节置换术的增多有关

2020-04-26 xiangting MedSci原创

HH与关节置换术的机率升高相关,尤其是老年人,这提示该年龄组的关节病进展更快。

遗传性血色病(HH)可能会引起铁沉积介导的关节病,从而导致进行性关节变性,必须进行关节置换。有研究表明,HH患者关节置换术的需求增多。这项研究目的是比较HH患者与非HH患者关节置换术的使用情况和住院经济负担。

这项回顾性队列研究使用了2014年全国住院患者样本。纳入国际疾病分类第九修订版HH编码的患者。主要结局是使用关节置换术。次要结局是住院时间、住院费用和总住院费用。使用多元logistic回归计算调整混杂因素后的比值比(ORs)和均值。

在18,250名HH患者中,7,483名(41.0%)是女性,1,155名患者(6.3%)接受了关节置换术。HH患者接受关节置换术的平均(SD)年龄为66岁(18)。HH患者接受关节置换术的百分比高于非HH患者(3.4%;P<.01)。通过多因素分析,与相应性别和年龄的非HH患者相比,HH年轻成年女性患者和老年患者更容易进行关节置换。只有年轻成年女性患者的平均住院时间、住院费用和总住院费用增加。

HH与关节置换术的机率升高相关,尤其是老年人,这提示该年龄组的关节病进展更快,临床医生应提高对HH患者的治疗意识。未来的研究应当确定介导HH患者关节病进展的因素。

原始出处:

Paul T. Kröner. Hereditary hemochromatosis is associated with increased use of joint replacement surgery: Results of a nationwide analysis. Semin Arthritis Rheu. April 2020.

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    2020-08-02 yxch48
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    2020-04-28 zhaojie88
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AAOS 2013:抑郁与全关节置换术(TJA)术后并发症风险增加有关

  根据周二(2013年3月19日)报告的研究数据显示,抑郁与全关节置换术(TJA)术后并发症风险增加有关,包括术后精神异常、贫血、肺栓塞(PE)和感染。研究还发现TJA患者中抑郁的诊断在增加。   作者强调,虽然就抑郁对TJA术后疼痛缓解和功能恢复的影响已有过研究,但是对于抑郁对术后并发症发生率和死亡率的影响知之甚少。他们尝试评估TJA患者中抑郁的诊断率,并确定其对于早期转归的影响。    

PLos One:骨关节炎疼痛的预后因素

这项研究结果表明,尽管OA患者在TJR后测试的临床和生物社会心理指标改变,但其术前值并不能预测术后疼痛。