Sci Rep：研究确定异黄酮提取物治疗银屑病的疗效及分子机制

2018-05-01 MedSci MedSci原创

牛皮癣是一种常见的炎症疾病，影响全球1-3％的人口，并且与每年增加的医疗费用有关。典型的牛皮癣皮肤病变是遍布全身的多个皮肤部位发生的红色、厚厚的鳞状斑块。咪喹莫特（IMQ）是一种toll样受体（TLR）7激动剂和有效的免疫系统激活剂，其局部应用可诱导和加重银屑病。既往研究表明异黄酮提取物具有抗氧化作用，可能有助于减轻炎症和炎症性疼痛。小鼠中体内研究中，我们发现，IMQ治疗前局部应用异黄酮提取物在小

牛皮癣是一种常见的炎症疾病，影响全球1-3％的人口，并且与每年增加的医疗费用有关。典型的牛皮癣皮肤病变是遍布全身的多个皮肤部位发生的红色、厚厚的鳞状斑块。咪喹莫特（IMQ）是一种toll样受体（TLR）7激动剂和有效的免疫系统激活剂，其局部应用可诱导和加重银屑病。既往研究表明异黄酮提取物具有抗氧化作用，可能有助于减轻炎症和炎症性疼痛。

小鼠中体内研究中，我们发现，IMQ治疗前局部应用异黄酮提取物在小鼠背部和右耳，可显著降低跨表皮水分流失（TEWL），红斑，血流速度和耳部斑块厚度，同时增加了表面皮肤水合作用，并减弱了表皮增生和炎性细胞浸润。体外实验显示，异黄酮提取物可减少正常人表皮角质形成细胞中的IL-22、IL-17A和TNF-α诱导的MAPK、NF-κB和JAK-STAT活化。在mRNA水平，我们确定异黄酮提取物减弱了TNF-α、IL-17A和IL-22相关通路的响应增加。

这些结果表明，异黄酮提取物作为抗银屑病剂和治疗其他炎症性皮肤病具有很大的潜力。

原始出处：

Hsin-Ju Li, Nan-Lin Wu, et al., The Therapeutic Potential and Molecular Mechanism of Isoflavone Extract against Psoriasis. Sci Rep. 2018; 8: 6335. doi: 10.1038/s41598-018-24726-z

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2018-05-15 isabellayj

#异黄酮#

46 0
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2018-07-06 fengyi821

#黄酮#

28 0
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2018-05-03 131****2916

不错的文章值得推荐

74 0
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2018-05-02 营养医师

只要做都有效

69 0
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2018-05-02 kafei

了解一下谢谢

65 0
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2018-05-02 神功盖世

阅

69 0
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2018-05-02 871538379

望普及临床感谢分享

71 0
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2018-05-02 121832a9m88暂无昵称

学习了

24 0
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2018-05-02 内科新手

谢谢梅斯提供这么好的信息，学到很多

28 0
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2018-05-02 飛歌

学习了很有用

32 0

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