Diabetologia:改善2型糖尿病患者血糖水平 午后or清晨锻炼更有效?

2019-02-13 王淳 环球医学

2019年2月,瑞典、挪威和丹麦学者发表在《Diabetologia》的一项随机交叉试验表明,午后锻炼比清晨锻炼在改善2型糖尿病患者血糖水平上更有效。

2019年2月,瑞典、挪威和丹麦学者发表在《Diabetologia》的一项随机交叉试验表明,午后锻炼比清晨锻炼在改善2型糖尿病患者血糖水平上更有效。

目的/假设:锻炼推荐用于2型糖尿病的治疗和预防。然而,尚不清楚一天当中实现健康获益效应的最有效的时间。研究者旨在确定在一天中的两个不同时间进行锻炼是否对2型糖尿病男性的24小时血糖水平具有差异化影响。

方法:11名2型糖尿病男性进行了随机交叉试验。入组标准为,45~68岁,BMI为23~33kg/m2。排除标准为,胰岛素治疗,存在另一种全身性疾病。研究者对分组不设盲。试验包括2周的清晨或午后高强度间歇训练(HIIT)(3次/周),接着是2周的磨合期,随后是相反锻炼方案期。获得了基于连续血糖监测(CGM)的数据。

结果:与锻炼前阶段(6.4±0.3mmol/L)或午后HIIT(6.2±0.3mmol/L;第一周运动日的平均±SEM)相比,清晨HIIT可增加基于CGM的血糖浓度(6.9±0.4mmol/L;第一周运动日的平均±SEM)。相反,与锻炼前阶段或清晨HIIT相比,午后HIIT可降低基于CGM的血糖浓度。与锻炼前阶段(TSH:1.4±0.2mU/L;T4:16.8±0.6pmol/L)相比,午后HIIT与促甲状腺激素的升高(TSH;1.9±0.2mU/L)和T4浓度的降低(15.8±0.7pmol/L)相关。清晨HIIT后,TSH也升高(1.7±0.2mU/L),T4浓度保持不变。

结论/意义:午后HIIT比清晨HIIT在改善2型糖尿病男性的血糖上更有效。值得注意的是,清晨HIIT具有急性有害影响,会增加血糖。然而,需要更长训练方案的研究来明确该不良反应的持续性。本研究的数据强调,当为2型糖尿病开具运动处方时,优化锻炼时间的重要性。

原始出处:

Savikj M, Gabriel BM, Alm PS, et.al. Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial. Diabetologia. 2019 Feb;62(2):233-237. doi: 10.1007/s00125-018-4767-z. Epub 2018 Nov 13.

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    2019-02-13 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2019-02-13 jingjing

    运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少

    0

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