J Pediatr:孕期吸入二手烟会影响后代神经系统发育(Rhea Study)

2015-04-16 Mechront 译 MedSci原创

众所周知吸烟有害身体健康,何况娇嫩的胎儿,必定难逃香烟的祸害。先前有不同的研究报道称,尿液中可替宁含量与二手烟的吸入密切相关。因此通过测定孕妇尿液中可替宁含量,可以推测没有吸烟史的孕妇其妊娠期二手烟暴露情况。

众所周知吸烟有害身体健康,何况娇嫩的胎儿,必定难逃香烟的祸害。先前有不同的研究报道称,尿液中可替宁含量与二手烟的吸入密切相关。因此通过测定孕妇尿液中可替宁含量,可以推测没有吸烟史的孕妇其妊娠期二手烟暴露情况。Evlampidou I等人对希腊克里特岛单胎妊娠、没有吸烟史的孕妇进行了一项调查,通过测定其尿液可替宁含量,推测孕期二手烟暴露情况,与其后代18月大时粗大运动功能发育情况。

希腊克里特岛的599孕妇中有175名 (29%)符合纳入标准。数据表明,孕妇尿液可替宁水平较低(平均: 10.3 ng/mL, SD: 11.7 ng/mL)。研究者校正潜在影响神经系统发育的混杂因素后发现,后代粗大运动发育情况与孕妇尿液可替宁含量密切相关。孕妇尿液可替宁含量越高,其后代不管男女,粗大运动功能不良的风险越高(beta = -3.22 per 10 ng/mL, 95% CI -5.09 to -1.34)。研究者们还观察到后代的认知和接受交流两方面也与孕妇尿液可替宁含量有关,只是该影响很小,没有统计学意义。

研究结果表明,对于没有吸烟史的孕妇妊娠期二手烟暴露(通过孕妇尿液测定可替宁含量推测孕期二手烟暴露情况)会导致后代18月大时粗大运动功能发育不良,就算是很小剂量的暴露,该影响也在所难免。可见其危害性足够大。

原始出处:


Evlampidou I, Bagkeris M, Vardavas C, Koutra K, Patelarou E, Koutis A, Chatzi L, Kogevinas M.Prenatal Second-Hand Smoke Exposure Measured with Urine Cotinine May Reduce Gross Motor Development at 18 Months of Age.J Pediatr. 2015 Apr 8. pii: S0022-3476(15)00253-X. doi: 10.1016/j.jpeds.2015.03.006.

本文系Medsci原创编译整理!转载需要先获得授权,并附原文链接。谢谢!

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    2016-01-10 feather89
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    2015-04-18 neurowu
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    2015-04-18 yanghan
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    2015-04-17 zhouanxiu

    吸烟有害

    0

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