Pharmacoepidemiol Drug Saf:ACEI竟与急性胰腺炎风险增加相关

2017-08-09 何娜 环球医学资讯

2017年7月,发表在《Pharmacoepidemiol Drug Saf》的一项由芬兰科学家进行的基于人群的病例对照研究,考察了血管紧张素转换酶抑制剂(ACEI)与急性胰腺炎风险之间的相关性。

2017年7月,发表在《Pharmacoepidemiol Drug Saf》的一项由芬兰科学家进行的基于人群的病例对照研究,考察了血管紧张素转换酶抑制剂(ACEI)与急性胰腺炎风险之间的相关性。

目的:旨在确定ACEI的使用和急性胰腺炎风险之间的相关性。

方法:2008~2010年因急性胰腺炎住院的4966例患者的信息从芬兰医院出院和处方国家注册中获取。使用密度抽样的方法,随机选取了总共24788个年龄和性别配对的基于人群的对照。2003年1月1日和指数日期之间的ACEI使用通过因急性胰腺炎而住院的日期确定。确定未诊断为胆汁或酒精诱导的急性胰腺炎的发病率比通过条件逻辑回归分析,并调整了合并症。

结果:总共1276例病例(26%)和3946例对照(16%)暴露于ACEI。ACEI的使用与急性胰腺炎发病率的增加相关(比值比OR,1.76;95% CI,1.59~1.95)。当前新使用者的增加稍微高(OR,1.86;1.65~2.09),当前使用者(OR,1.54;1.35~1.75)和之前使用者(OR,1.51;1.31~1.74)稍低。

结论血管紧张素转换酶抑制剂的使用与急性胰腺炎风险中度增加相关。

原始出处:
Kuoppala J, Enlund H, Pulkkinen J,et al.ACE inhibitors and the risk of acute pancreatitis-a population-based case-control study.Pharmacoepidemiol Drug Saf. 2017 Jul;26(7):853-857. doi: 10.1002/pds.4179. Epub 2017 Mar 1.

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    2018-04-18 yb6560
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    2018-02-14 jj000001
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    2017-12-24 仁者大医
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    2018-06-07 爆笑小医
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    2017-08-12 孙文杰

    受益匪浅

    0

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    2017-08-09 189****7206

    学习了谢谢分享

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    2017-08-09 131****1460

    学习了受益匪浅。

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