Lancet Gastr Hepat:肠道微生物如何导致小儿肝病?

2017-06-07 qinqiyun MedSci原创

2013年肠道菌群与人体健康关系的研究被列入“Science”杂志发表的十大科学进展。多项研究发现肠道菌群对人类健康有重要影响,如肝脏。但目前,肠道菌群如何影响肝脏疾病,尚不清楚。

2013年肠道菌群与人体健康关系的研究被列入“Science”杂志发表的十大科学进展。多项研究发现肠道菌群对人类健康有重要影响,如肝脏。但目前,肠道菌群如何影响肝脏疾病,尚不清楚,近期,Lancet子刊上发表了一篇关于肠道微生物与小儿肝病进展的关系的文章。

在近期研究中,肠道微生物受到广泛关注,但是,微生物如何影响相关连的器官(例如肝脏)尚不清楚。肠道微生物可以调节肠粘膜的渗透性并帮助将食物分解成小分子,从而直接影响肝脏健康。多项研究发现肠道菌群失调与肝脏疾病的严重程度和进展相关联,如非酒精性脂肪肝、非酒精性脂肪性肝炎、原发性硬化性胆管炎、全肠道外营养相关性肝病和囊性纤维化相关性肝病。但是,尚没有足够的信息可以解释微生物如何在小儿中导致这些肝病。因为在出生时,肠内菌群存在很大差异,而且,3岁后菌群才会建立稳定的定植。临床研究表明小儿肝病在进展的严重性及概率均与成年人的不同,说明小儿肝病可能有其独立的发病机制。研究者们在本文中论述关于肠道菌群与肝病进展的联系和改变儿童肠内微生物的治疗方式。

原始出处:

Daniel h leung,Dr Dean Yimlamai.The intestinal microbiome and paediatric liver disease.The lancet Gastroenter Hepatol.June,2017.Vol.2,No.6.http://dx.doi.org/10.1016/S2468-1253(16)30241-2


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    2017-09-16 howi
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    2018-01-17 许安
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    2017-06-09 gwc384
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    2017-06-08 一个字-牛

    学习了谢谢分享

    0

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    2017-06-07 Y—xianghai

    学习了新知识

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    2017-06-07 rjchwd

    微生物的角色这么重要!

    0

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