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Heart：房颤患者cTnI 和NT-proBNP持续升高提示预后不良

2014-05-05 永远 编译 中国医学论坛报CMT心血管微信

房颤患者cTnINT-proBNP预后不良
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RE-LY试验亚组分析显示，在房颤患者中，与肌钙蛋白I(cTnI)和N末端脑钠肽前体(NT-proBNP)水平短暂升高或不升高相比，这两种标志物水平持续升高提示患者预后较差。重复测定这些心脏标志物水平可改善卒中、死亡和心血管事件的预后。论文5月2日在线发表于《心脏》(heart)杂志。 研究纳入RE-LY试验的2514例心房颤动患者，随机分组和3个月后采血样测定cTnI和NT-proBNP水平，

RE-LY试验亚组分析显示，在房颤患者中，与肌钙蛋白I(cTnI)和N末端脑钠肽前体(NT-proBNP)水平短暂升高或不升高相比，这两种标志物水平持续升高提示患者预后较差。重复测定这些心脏标志物水平可改善卒中、死亡和心血管事件的预后。论文5月2日在线发表于《心脏》(heart)杂志。



研究纳入RE-LY试验的2514例心房颤动患者，随机分组和3个月后采血样测定cTnI和NT-proBNP水平，中位随访2年。

结果显示，在两个时间点均可检出cTnI的患者比例为48.5%，在两个时间点均可检出cTnI的患者卒中发生率显著高于在任一时间点cTnI水平短暂升高或不升高的患者(P<0.005)。基线和3个月时，一种或两种心脏生物标志物水平持续升高与心血管事件及死亡风险较高有关(P<0.0001)。同时重复测定两种心脏生物标志物水平，对预后的预测准确性最高(P<0.05)。


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    2014-08-01 shanyongle

    #cTnI#

    0

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    2014-05-07 huiwelcome

    #BNP#

    0

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    2014-05-07 mjldent

    #NT-proBNP#

    0

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    2014-05-07 zhaojie88

    #ART#

    0

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    2014-05-07 caoliehu

    #预后不良#

    0

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    2014-05-07 爆笑小医

    #HEART#

    0

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    2014-05-07 sunylz

    #PRO#

    0

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    2014-05-07 hittouch

    #房颤患者#

    0

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