J Oral Rehabil:牙齿缺失而引起肠易激综合征

2015-05-09 MedSci MedSci原创

J Oral Rehabil:牙齿缺失而引起肠易激综合征肠易激综合征(IBS)是最常见的功能性胃肠性疾病。目前已经确定造成IBS的几个因素,包括,肠道功能异常,内脏感觉过敏,炎症,神经递质失衡,脑–肠互动障碍,自主神经和激素原因,遗传,环境和社会心理因素等。牙齿丧失是影响咀嚼功能的最常见原因,牙齿丧失是非常普遍的全球性问题。食物咀嚼不充分和暴露于唾液的时间减少可导致其预发酵不足,影响了食团的形成,





肠易激综合征(IBS)是最常见的功能性胃肠性疾病。目前已经确定造成IBS的几个因素,包括,肠道功能异常,内脏感觉过敏,炎症,神经递质失衡,脑–肠互动障碍,自主神经和激素原因,遗传,环境和社会心理因素等。


牙齿丧失是影响咀嚼功能的最常见原因,牙齿丧失是非常普遍的全球性问题。食物咀嚼不充分和暴露于唾液的时间减少可导致其预发酵不足,影响了食团的形成,造成胃酸分泌不足,其结果是引起了消化功能紊乱和造成机体较差的营养状况。

虽然牙齿数目与胃肠功能紊乱之间的关系已被确定,但是,关于牙齿缺失IBS之间关系的研究去很有限。本研究的目的是为了探讨伊朗成人中牙齿丧失与IBS之间的关系。

采用横断面调查研究,纳入4669名伊朗成人,使用问卷调查方式评价参与者的牙齿状况。将参与者分为五类:完整牙列(无义齿),缺失1-2颗牙齿者,缺失3-5颗牙齿者,缺失半口或更多牙者。采用罗马III标准确定IBS及其亚型。校正了混杂因素后,缺失1-2和3-5颗牙齿的参与者患IBS的几率分别为完整牙列参与者的1.35和1.33倍。控制不同的混杂因素后,相对于完整牙列的参与者,佩戴义齿的参与者患便秘型IBS的机会高103% (95% 可信区间为129–321)。

无论是校正混杂因素之前还是校正混杂因素之后,参与者的牙齿状况与IBS其他亚型之间均无显著地关联。另外,我们发现,缺失1-2颗牙齿或者缺失3-5颗牙齿可能会明显增加IBS发生的危险。义齿可能与便秘型IBS有关,仍需要更多地前瞻性研究以进一步确定本研究的发现。

MedSci点评:这项研究虽然证据等级还不高,但是研究的思路却是值得大为赞赏!对于两个本来可能风马牛的事情,却被牵连在一起。

当然,MedSci小编询问了公司的学术专家,学术专家认为,这个研究对于年龄因素应该进行特别分层,因为随着年龄增长,牙齿自然会减少,同样IBS可能增加,二者可能不一定有必然联系。因此,要在不同年龄段中,进一步分析牙齿缺失与IBS的关系。

原始出处:

Esmaillzadeh A, Keshteli AH, Saneei T, Saneei P, Savabi O, Adibi P. Is tooth loss associated with irritable bowel syndrome? J Oral Rehabil. 2015 Jan 27. doi: 10.1111/joor.12277.

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2015-11-25 小几洁
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    2015-05-13 huaxipanxing

    看看

    0

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    2015-05-11 zhouqu_8
  5. [GetPortalCommentsPageByObjectIdResponse(id=125087, encodeId=22fc12508e24, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:57:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020171, encodeId=1f6920201e1d5, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Wed Nov 25 05:45:00 CST 2015, time=2015-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23467, encodeId=f37d2346e4a, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:27:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430052, encodeId=0dcf14300520c, content=<a href='/topic/show?id=b58f6e691fc' target=_blank style='color:#2F92EE;'>#牙齿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67691, encryptionId=b58f6e691fc, topicName=牙齿)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon May 11 07:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430521, encodeId=55a2143052133, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon May 11 07:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521845, encodeId=215c15218455f, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Mon May 11 07:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23116, encodeId=48ff2311677, content=如果是这样,混杂因素是否包括了年龄?, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=131a85729, createdName=1381516dc4m, createdTime=Sun May 10 17:43:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23103, encodeId=229a23103ad, content=评论精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun May 10 16:08:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=125087, encodeId=22fc12508e24, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:57:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020171, encodeId=1f6920201e1d5, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Wed Nov 25 05:45:00 CST 2015, time=2015-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23467, encodeId=f37d2346e4a, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:27:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430052, encodeId=0dcf14300520c, content=<a href='/topic/show?id=b58f6e691fc' target=_blank style='color:#2F92EE;'>#牙齿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67691, encryptionId=b58f6e691fc, topicName=牙齿)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon May 11 07:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430521, encodeId=55a2143052133, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon May 11 07:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521845, encodeId=215c15218455f, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Mon May 11 07:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23116, encodeId=48ff2311677, content=如果是这样,混杂因素是否包括了年龄?, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=131a85729, createdName=1381516dc4m, createdTime=Sun May 10 17:43:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23103, encodeId=229a23103ad, content=评论精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun May 10 16:08:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-11 qjddjq
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    2015-05-10 1381516dc4m

    如果是这样,混杂因素是否包括了年龄?

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=125087, encodeId=22fc12508e24, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:57:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020171, encodeId=1f6920201e1d5, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Wed Nov 25 05:45:00 CST 2015, time=2015-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23467, encodeId=f37d2346e4a, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:27:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430052, encodeId=0dcf14300520c, content=<a href='/topic/show?id=b58f6e691fc' target=_blank style='color:#2F92EE;'>#牙齿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67691, encryptionId=b58f6e691fc, topicName=牙齿)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon May 11 07:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430521, encodeId=55a2143052133, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon May 11 07:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521845, encodeId=215c15218455f, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Mon May 11 07:45:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23116, encodeId=48ff2311677, content=如果是这样,混杂因素是否包括了年龄?, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=131a85729, createdName=1381516dc4m, createdTime=Sun May 10 17:43:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23103, encodeId=229a23103ad, content=评论精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun May 10 16:08:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-10 223.104.5.**

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