JAHA:心肌肌钙蛋白I可预测冠心病风险

2017-08-01 MedSci MedSci原创

老年女性是冠心病和心衰的高发人群。现在高灵敏的检测手段可以检测出急性冠脉综合征患者微量的肌钙蛋白I(hsTnI)。近日,在国际心血管权威杂志JAHA上发表了一篇旨在评估年龄超过70岁的白种女性的hsTnI水平与心血管不良事件相关性的临床研究。本研究共纳入了1081名老年女性,在研究起始(1998),所有研究对象均没有冠心病和可以诊断为急性冠脉综合征的高hsTnI水平,平均随访时间是14.5年,对其

老年女性是冠心病和心衰的高发人群。现在高灵敏的检测手段可以检测出急性冠脉综合征患者微量的肌钙蛋白I(hsTnI)。近日,在国际心血管权威杂志JAHA上发表了一篇旨在评估年龄超过70岁的白种女性的hsTnI水平与心血管不良事件相关性的临床研究。

本研究共纳入了1081名老年女性,在研究起始(1998),所有研究对象均没有冠心病和可以诊断为急性冠脉综合征的高hsTnI水平,平均随访时间是14.5年,对其住院情况和死亡率进行了统计分析。最终,有243名(22%)女性患有冠心病,有163名(15%)女性出现心肌梗塞或冠心病源性死亡,109名(10%)女性出现心衰。在99.6%的可用血清样本中,hsTnI均高于检测水平(中位数为4.5ng/L;间距范围,3.6-5.8)。在调整Framingham危险因素后,每个SD自然对数‐转化hsTnI的增加与冠心病的危险性增加有关(HR 1.34; 95% CI, 1.18-1.53; P<0.001),与严重的冠心病事件有关(HR 1.51; 95% CI, 1.29-1.76; P<0.001),与心衰的发生也呈相关性(HR 1.65; 95% CI, 1.36-1.99; P<0.001)。

研究结果表明,心肌肌钙蛋白I的水平在无明显临床症状的老年女性中与心血管不良事件的发生呈相关性,将心肌肌钙蛋白I与常规危险因素联合起来可能有助于不良事件的风险预测。

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    2017-09-26 尉志鹏

    值得学习

    0

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    2017-08-04 大爰

    学习了谢谢分享!!

    0

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    2017-08-03 zhaohui6731
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    2017-08-02 lou.minghong

    学习了谢谢分享!

    0

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