Crit Care:心源性休克患者开始24小时平均动脉压与住院死亡率之间的关系

2020-08-22 MedSci原创 MedSci原创

在CS患者中,研究人员观察到mMAP24与住院死亡率之间存在负相关。mMAP24<65mmHg患者的不良预后为将CS患者的MAP目标值设定为65 mmHg提供了间接证据。

心源性休克(CS)患者的最佳平均动脉压(MAP)目标范围尚未明确。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,研究人员试图明确心脏重症监护病房(CICU)CS患者的MAP与死亡率之间的关系。

研究人员使用2007年至2015年期间收治的CICU患者单中心数据库,确定了入院诊断为CS的患者。每15分钟测量一次MAP,并记录前24小时内所有MAP的平均值(mMAP24)。研究人员采用多变量logistic回归确定了mMAP24与调整后住院死亡率之间的关系。

研究人员纳入了1002例平均年龄为68±13.7岁的患者,其中36%为女性。入院诊断包括60%的急性冠状动脉综合征患者,74%的心力衰竭患者和38%的心脏骤停患者。血管活性药物的使用率为72%。与非幸存者(34%)相比,住院幸存者(66%)中的mMAP24更高(75 vs. 71 mmHg,p<0.001)。医院死亡率与mMAP24呈负相关(调整后的mMAP24每升高5mmHg的OR为0.9,p=0.01),而mMAP24较低,则住院死亡率逐步增加。mMAP24<65mmHg的患者发生住院死亡的风险更高(57% vs. 28%,校正后的OR为2.0,95%CI为1.4-3.0,p<0.001);mMAP24为65-74 vs. ≥75mmHg的患者之间无差异(p>0.1)。

由此可见,在CS患者中,研究人员观察到mMAP24与住院死亡率之间存在负相关。mMAP24<65mmHg患者的不良预后为将CS患者的MAP目标值设定为65 mmHg提供了间接证据。

原始出处:

Barry Burstein.et al.Association between mean arterial pressure during the first 24 hours and hospital mortality in patients with cardiogenic shock.Critical Care.2020.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03217-6

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    2020-08-24 chengjn
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    2020-08-24 yhthzx

    学习了

    0

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beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200823/ece0a24ea5824924b9ba0b87a5947f86/11f20d29045c49fd9671ef69fa0c4012.jpg, createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:07:46 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2020-08-24 杀无敌战神

    学习

    0

  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200823/ece0a24ea5824924b9ba0b87a5947f86/11f20d29045c49fd9671ef69fa0c4012.jpg, createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:07:46 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
  6. 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  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200823/ece0a24ea5824924b9ba0b87a5947f86/11f20d29045c49fd9671ef69fa0c4012.jpg, createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:07:46 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2020-08-24 mhm295
  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200823/ece0a24ea5824924b9ba0b87a5947f86/11f20d29045c49fd9671ef69fa0c4012.jpg, createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:07:46 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2020-08-23 ms7000000689223974

    很详细,很赞

    0

  9. 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encodeId=77078125663d, content=很详细,很赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200823/ece0a24ea5824924b9ba0b87a5947f86/11f20d29045c49fd9671ef69fa0c4012.jpg, createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 21:58:22 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812532, encodeId=d69d8125320c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f62b1328803, createdName=hebeizhoujian, createdTime=Sun Aug 23 20:56:33 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812527, encodeId=709181252eb1, content=讲的很详细,很有用,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200823/ece0a24ea5824924b9ba0b87a5947f86/11f20d29045c49fd9671ef69fa0c4012.jpg, createdBy=f64a5412720, createdName=ms7000000689223974, createdTime=Sun Aug 23 20:07:46 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2020-08-23 hebeizhoujian

    学习

    0

  10. 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    2020-08-23 ms7000000689223974

    讲的很详细,很有用,赞一个

    0

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