Gut:急性下消化道出血患者最应小心的不是出血而是…

2018-05-10 吴星 环球医学

2018年4月,发表于《Gut》上的一项研究,考察了英国急性下消化道出血(LGIB)患者的特征、干预和结局。

2018年4月,发表于《Gut》上的一项研究,考察了英国急性下消化道出血(LGIB)患者的特征、干预和结局。

目的:尽管缺乏报告、干预和结局的数据,但LGIB是急性住院的常见原因。在这次英国的全国性审查中,研究者描述了患者的特征、包括内窥镜检查、放射学检查和外科手术在内的干预措施以及临床结局。

设计:对2015年因LGIB去英国医院住院超过2个月的成人患者进行多中心审查。临床团队前瞻性地纳入连续性病例,并随访28天。

结局:143家医院提供了2528例LGIB病例数据。大多是伴有严重合并症的老年人(中位年龄,74岁),29.4%服用抗血小板药物和15.9%服用抗凝剂。休克是不常见事件(58/2528,2.3%),但666名(26.3%)患者接受了红细胞输注。可弯曲乙状结肠镜检查是最常见的检查(21.5%),但仅有2.1%的患者接受内镜止血。很少使用栓塞或手术治疗,分别有19例(0.8%)和6例(0.2%)。48%患者未接受住院调查。最常见的诊断是憩室出血(26.4%)和良性肛肠疾病(16.7%)。中位住院时间为3天,13.6%的患者在住院期间再出血,4.4%患者28天内因出血再住院。院内死亡率为85/2528(3.4%),在已确认的住院患者(17.8%,p<0.0001)和再出血的患者(7.1%,p<0.0001)中死亡率最高。

结论:LGIB患者合并症负担高,而且经常使用抗血小板和抗凝药物。红细胞输注较常见,但大多数患者没有休克,也不需要内窥镜、放射学检查和手术治疗。近一半患者没有接受住院调查。院内死亡率与合并症相关,与严重出血不相关。

原始出处:

Facon T, et al. Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma. Blood. 2018 Jan 18;131(3):301-310. doi: 10.1182/blood-2017-07-795047.

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    2018-05-12 cscdliu

    学习了.谢谢

    0

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    2018-05-12 121832a9m88暂无昵称

    学习了

    0

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    2018-05-11 邓启付

    下消化道出血最常见的是憩室出血和良性病变出血.

    0

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    2018-05-11 秀红

    学习了

    0

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    2018-05-10 惠映实验室

    学习了.谢谢分享.

    0

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