加拿大学者发现服用抗抑郁药可能加倍增加患痴呆症的风险

2017-02-24 佚名 科技部

加拿大萨斯喀彻温大学的研究人员采用医学文献研究方法,发现位列全球处方药前列的抗抑郁药,有可能助长阿尔茨海默症和其他脑损伤痴呆症的发生。研究团队利用医学文献研究方法,对4123篇医学文章进行筛选,最后选择出5篇符合他们研究标准的文章,这5篇文章共涉及约150万人。



加拿大萨斯喀彻温大学的研究人员采用医学文献研究方法,发现位列全球处方药前列的抗抑郁药,有可能助长阿尔茨海默症和其他脑损伤痴呆症的发生。研究团队利用医学文献研究方法,对4123篇医学文章进行筛选,最后选择出5篇符合他们研究标准的文章,这5篇文章共涉及约150万人。

研究发现,服用比较受欢迎的被称为选择性5-羟色胺再摄取抑制剂(SSRIs)的一种治疗精神抑郁的药以及其它抗抑郁药,与包括阿尔茨海默症在内的一些痴呆症发病率加倍增长密切相关。年龄对服用抗抑郁药和患认知损害疾病或阿尔茨海默症/痴呆症之间有相关影响,平均年龄在65岁以上服用抗抑郁药的人患认知损害疾病的几率会增加。相关研究成果发表在2016年12月28日的《抑郁和焦虑》(Depression and Anxiety)杂志上。

该研究虽然没有证明原因和结果,但是,他们的发现会激发起人们对一系列抗抑郁药物的关注。这些药物被广泛和不加选择地用于治疗从普通的“悲伤”到失眠、疼痛和热潮红等各种疾病。抗抑郁药虽然对一些人确实有用,但研究人员确实发现抗抑郁药与痴呆之间有相关性。科学家一直在寻找导致痴呆症的因素,抑郁症可能是其中一个因素,但不是每一个有抑郁的人会得阿尔茨海默病,也不是每一个患阿尔茨海默病的人会都有抑郁症。

加拿大位列世界抗抑郁药使用前列,根据IMS Brogan公司的市场研究,加拿大2015年开出超过5千万份抗抑郁药处方。同时,由于人的寿命增长,得阿尔茨海默症和其他脑疾病的人在增加。目前全球约有4750万人患痴呆症,加拿大有75万人,预计在未来15年会增加一倍。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1836141, encodeId=bf401836141ba, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Jun 30 11:22:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722447, encodeId=3ef51e2244734, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Jun 27 23:22:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178161, encodeId=8dac1e81610c, content=新视角,有探索有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/EAA0B8CCF229D6D96848A3C1ADD02B9A/100, createdBy=45aa1721648, createdName=QQ713279ab, createdTime=Tue Feb 28 07:39:51 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312543, encodeId=118613125431e, content=<a href='/topic/show?id=1aa333006b4' target=_blank style='color:#2F92EE;'>#加拿大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33006, encryptionId=1aa333006b4, topicName=加拿大)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492167, encodeId=8a67149216ed0, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=)]
    2017-06-30 Boyinsh
  2. [GetPortalCommentsPageByObjectIdResponse(id=1836141, encodeId=bf401836141ba, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Jun 30 11:22:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722447, encodeId=3ef51e2244734, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Jun 27 23:22:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178161, encodeId=8dac1e81610c, content=新视角,有探索有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/EAA0B8CCF229D6D96848A3C1ADD02B9A/100, createdBy=45aa1721648, createdName=QQ713279ab, createdTime=Tue Feb 28 07:39:51 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312543, encodeId=118613125431e, content=<a href='/topic/show?id=1aa333006b4' target=_blank style='color:#2F92EE;'>#加拿大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33006, encryptionId=1aa333006b4, topicName=加拿大)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492167, encodeId=8a67149216ed0, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=)]
    2017-06-27 wetgdt
  3. [GetPortalCommentsPageByObjectIdResponse(id=1836141, encodeId=bf401836141ba, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Jun 30 11:22:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722447, encodeId=3ef51e2244734, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Jun 27 23:22:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178161, encodeId=8dac1e81610c, content=新视角,有探索有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/EAA0B8CCF229D6D96848A3C1ADD02B9A/100, createdBy=45aa1721648, createdName=QQ713279ab, createdTime=Tue Feb 28 07:39:51 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312543, encodeId=118613125431e, content=<a href='/topic/show?id=1aa333006b4' target=_blank style='color:#2F92EE;'>#加拿大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33006, encryptionId=1aa333006b4, topicName=加拿大)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492167, encodeId=8a67149216ed0, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=)]
    2017-02-28 QQ713279ab

    新视角,有探索有收获

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1836141, encodeId=bf401836141ba, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Jun 30 11:22:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722447, encodeId=3ef51e2244734, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Jun 27 23:22:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178161, encodeId=8dac1e81610c, content=新视角,有探索有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/EAA0B8CCF229D6D96848A3C1ADD02B9A/100, createdBy=45aa1721648, createdName=QQ713279ab, createdTime=Tue Feb 28 07:39:51 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312543, encodeId=118613125431e, content=<a href='/topic/show?id=1aa333006b4' target=_blank style='color:#2F92EE;'>#加拿大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33006, encryptionId=1aa333006b4, topicName=加拿大)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492167, encodeId=8a67149216ed0, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1836141, encodeId=bf401836141ba, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Jun 30 11:22:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722447, encodeId=3ef51e2244734, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Jun 27 23:22:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178161, encodeId=8dac1e81610c, content=新视角,有探索有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/EAA0B8CCF229D6D96848A3C1ADD02B9A/100, createdBy=45aa1721648, createdName=QQ713279ab, createdTime=Tue Feb 28 07:39:51 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312543, encodeId=118613125431e, content=<a href='/topic/show?id=1aa333006b4' target=_blank style='color:#2F92EE;'>#加拿大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33006, encryptionId=1aa333006b4, topicName=加拿大)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492167, encodeId=8a67149216ed0, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Feb 26 12:22:00 CST 2017, time=2017-02-26, status=1, ipAttribution=)]

相关资讯

2015BAP循证指南——抗抑郁药治疗抑郁症(修订2008版)发布

2015年5月,英国精神药理协会(BAP)发布了抗抑郁药治疗抑郁症指南,该指南是对2008年版指南的修订版本。全文获取:下载地址:指南下载 (需要扣积分2分, 梅斯医学APP免积分下载)

2015 ABM临床方案#18:母乳喂养女性抗抑郁药的应用

2015年7月,母乳喂养医学会(ABM)发布了母乳喂养女性抗抑郁药的应用指南。产后抑郁是一种比较常见且严重的产后状态,影响了10-20%的产后一年内的女性。本文主要内容涉及产后抑郁的筛查、影响以及临床治疗等内容。全文获取:下载地址:指南下载 (需要扣积分2分, 梅斯医学APP免积分下载) 

Am J Psychiatry:营养补充剂可提高抗抑郁药的疗效

来自澳大利亚墨尔本大学的一项系统性回顾分析表明,对于正在接受抑郁治疗的患者来说,服用营养补充剂,如omega 3鱼油,能显著提高抗抑郁药的效果。