Am J Psychiatry:营养补充剂可提高抗抑郁药的疗效

2016-04-29 MedSci MedSci原创

来自澳大利亚墨尔本大学的一项系统性回顾分析表明,对于正在接受抑郁治疗的患者来说,服用营养补充剂,如omega 3鱼油,能显著提高抗抑郁药的效果。

来自澳大利亚墨尔本大学的一项系统性回顾分析表明,对于正在接受抑郁治疗的患者来说,服用营养补充剂,如omega 3鱼油,能显著提高抗抑郁药的效果。

研究人员系统地搜索了1015年12月之前发表的使用辅助营养治疗抑郁症的临床试验。最后共纳入了然40项研究,研究时间至少为21天和样本量至少为10,每手臂(平均样本量为63)。

其中九项研究探究了叶酸、甲基叶酸盐、亚叶酸或联合叶酸、维生素B6和B12;八项研究探究了各种形式的色氨酸或其衍生物;四项研究探究了S-腺苷甲硫氨酸;八项研究探究了omega 3鱼油。进一步的研究是锌、肌醇、维生素C和维生素D。

omega 3鱼油的汇总数据显示omega 3鱼油可显著提高抗抑郁药的疗效。敏感性分析表明,这只限于探究了二十碳五烯酸的研究。

八项探究色氨酸的研究中其中四个研究表明,与安慰剂或对照组相比,辅助营养治疗存在积极的效果。汇总分析表明叶酸组和安慰剂组之间并无显著性差异。

S-腺苷甲硫氨酸和维生素D治疗的研究结果也显示了营养治疗的益处。关于锌和维生素C治疗的研究其结果各异。

“从我们的研究发现来看,omega 3鱼油联合抗抑郁药的治疗效果显著优于安慰剂的效果,” 该研究第一作者Jerome Sarris说道,“许多研究表明,omega 3s有益于大脑健康并改善心情,但是该研究首次分析了omega 3s与抗抑郁药物联合使用的研究。”

Sarris补充道,“与安慰剂相比,服用抗抑郁药和omega 3患者的差异有极显著的意义。这是一个令人兴奋的发现,因为在这里我们有一个安全的且有证据支持的方法,可看作是一种主流的治疗方法。”

但是,Sarris同时还指出许多研究的样本量较小,各研究之间存在相当大的异质性,而且各研究使用药物也不相同。目前该研究小组正在进行一项研究,探究营养补充剂组合应用治疗抑郁的效果。

原始出处:

Sarris J, Murphy J, Mischoulon D, Papakostas GI, Fava M, Berk M, Ng CH. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. Am J Psychiatry. 2016 Apr 26:appiajp201615091228.

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    2017-02-03 wetgdt
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    2016-05-02 jjzouyan

    赶快补充

    0

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    2016-05-01 明崖

    抑郁症的疗法改进

    0

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    2016-04-30 1de11f7fm56(暂无匿称)

    学习新知识了

    0

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    2016-04-30 Lisa971

    相关性。

    0

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