Sci Rep:种植体超声波洁治或可导致骨溶解

2017-08-10 MedSci MedSci原创

每年数以百万计的新型牙科和整形外科种植体的植入,种植体周围骨溶解成为了一个重大问题。种植体周围炎的管理主要包括超声波洁治。本研究中,研究人员探究了超声洁治是否或导致钛颗粒的释放并引起炎症和骨溶解。对机械加工、喷砂/酸蚀和喷砂处理表面得钛片进行超声波洁治,然后从物理和化学角度表征这些释放的粒子。结果显示,这些钛粒子可诱导巨噬细胞发生严重的炎症反应,并可刺激破骨细胞的形成。释放的粒子数量及其化学成分和

每年数以百万计的新型牙科和整形外科种植体的植入,种植体周围骨溶解成为了一个重大问题。种植体周围炎的管理主要包括超声波洁治。本研究中,研究人员探究了超声洁治是否或导致钛颗粒的释放并引起炎症和骨溶解。

对机械加工、喷砂/酸蚀和喷砂处理表面得钛片进行超声波洁治,然后从物理和化学角度表征这些释放的粒子。

结果显示,这些钛粒子可诱导巨噬细胞发生严重的炎症反应,并可刺激破骨细胞的形成。释放的粒子数量及其化学成分和纳米形貌可明显影响炎症反应。喷砂处理的钛片表面释放的粒子数量最多,钛片表面的纳米粗糙度也最明显。喷砂酸蚀处理的钛片所释放的颗粒诱导炎症反应轻于喷砂处理方式,但是强于机械加工方式。

然后将这些钛颗粒植入至纤维蛋白膜上,并置于小鼠颅骨5周。使用微型CT观察,发现喷砂处理来源的钛粒子诱导的骨溶解较喷砂/酸蚀处理的严重。

总之,该研究结果表明,超声波洁治植体所释放的钛粒子与钛表面处理方式有关,且可能会加重种植体周围炎。未来的研究应该评估表面粗糙度是否影响植体磨损颗粒的释放程度以及植体的无菌松动情况。

原始出处:

Michal Eger, Nir Sterer, et al., Scaling of titanium implants entrains inflammation-induced osteolysis. Sci Rep. 2017; 7: 39612. Published online 2017 Jan 6. doi: 10.1038/srep39612.

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    2018-01-16 huangdf
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    2018-01-06 yyj074
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    2017-08-10 130****4638

    学习了受益匪浅

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