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Clin Chem：心肌肌钙蛋白时间动态变化与普通人群的心血管事件风险

2019-07-20 gladiator MedSci原创

健康研究
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在一般人群中，心肌肌钙蛋白与心血管风险相关，但心肌肌钙蛋白I的时间变化是否可提供独立的预后信息仍不确定。在此，研究人员使用一个以社区为基础的大型队列，跟踪调查了心脏肌钙蛋白的时间变化与心血管事件之间的关系。 测量与高灵敏度测定心肌肌钙蛋白I (hs-cTnI) 4805年参与者参加第二(HUNT2,1995 - 97)和第三次(HUNT2006 - 2008)的前瞻性Nord-Trøndel

在一般人群中，心肌肌钙蛋白与心血管风险相关，但心肌肌钙蛋白I的时间变化是否可提供独立的预后信息仍不确定。在此，研究人员使用一个以社区为基础的大型队列，跟踪调查了心脏肌钙蛋白的时间变化与心血管事件之间的关系。

测量与高灵敏度测定心肌肌钙蛋白I (hs-cTnI) 4805年参与者参加第二(HUNT2,1995 - 97)和第三次(HUNT2006 - 2008)的前瞻性Nord-Trøndelag卫生(HUNT)研究。研究团队构建了从HUNT 2到HUNT 3 hs-cTnI的相对变化和绝对变化的统计模型。产生心血管死亡或心肌梗死或心力衰竭首次入院的复合终点。

hs-cTnI相对下降的患者多为年轻女性，血压和体重指数较低。hs-cTnI相对增高者多为老年男性，收缩压较高。hs-cTnI相对增加的校正危险率(HR)为1.68 (95% CI, 1.16-2.42)，相对减少的校正危险率为1.19 (95% CI, 0.84-1.68)。hs-cTnI的绝对升高与hs-cTnI的相对升高具有相似的预后特性。最新的hs-cTnI的测量结果在识别和重新分类模型上优于变化变量。

hs-cTnI的相对和绝对升高均与心血管风险独立相关。为了改进风险预测模型，临床实践中应优先采用最新的hs-cTnI测量方法。

原始出处：

Magnus N. Lyngbakken, Helge Røsjø,Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study

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    2019-10-12 hukaixun

    #血管事件#

    0

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    2020-01-25 仁医06

    #动态变化#

    0

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    2019-07-22 zhanfl

    #心血管事件风险#

    0

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    2019-07-22 wrj0124

    #心肌肌钙蛋白#

    0

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    2019-07-22 ms9476844295372110

    #普通人群#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1643625, encodeId=283516436257b, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Sat Oct 12 05:30:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1954389, encodeId=5043195438985, content=<a href='/topic/show?id=f42e330843a' target=_blank style='color:#2F92EE;'>#动态变化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33084, encryptionId=f42e330843a, topicName=动态变化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Jan 25 01:30:00 CST 2020, time=2020-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287669, encodeId=5ab6128e6693a, content=<a href='/topic/show?id=3c3d51e4459' target=_blank style='color:#2F92EE;'>#心血管事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51744, encryptionId=3c3d51e4459, topicName=心血管事件风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Mon Jul 22 14:30:00 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490322, encodeId=32b514903226b, content=<a href='/topic/show?id=72a651322e0' target=_blank style='color:#2F92EE;'>#心肌肌钙蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51322, encryptionId=72a651322e0, topicName=心肌肌钙蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1de58724110, createdName=wrj0124, createdTime=Mon Jul 22 14:30:00 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614773, encodeId=bd631614e73dd, content=<a href='/topic/show?id=b77f59959f2' target=_blank style='color:#2F92EE;'>#普通人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59959, encryptionId=b77f59959f2, topicName=普通人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b9519540847, createdName=ms9476844295372110, createdTime=Mon Jul 22 14:30:00 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370043, encodeId=e9d13e00430f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/07/06/59fb0f385948bdca2b3b8defa9b776d1.jpg, createdBy=27ef5133121, createdName=逆鳞⊙ω⊙, createdTime=Sun Jul 21 10:30:03 CST 2019, time=2019-07-21, status=1, ipAttribution=)]
    2019-07-21 逆鳞⊙ω⊙

    学习

    0