Biol Trace Elem Res:口服镁补充剂可改善糖尿病肾病患者的血脂状况,但增加其胰岛素抵抗

2020-06-16 MedSci原创 MedSci原创

血清镁浓度低与肾衰竭的发生有关。我们旨在确定补充镁是否能改善糖尿病肾病患者的肾功能、胰岛素抵抗和代谢情况。

血清镁浓度低与肾衰竭的发生有关。我们旨在确定补充镁是否能改善糖尿病肾病患者的肾功能、胰岛素抵抗和代谢情况。

 

我们共招募了80名被诊断为2型糖尿病和早期肾病的低镁血症患者。受试者每天接受氧化镁或安慰剂治疗12周。生化和人体测量变量被测量。还记录了身体活动和饮食摄入量。

 

结果显示,血清镁水平没有显著变化。虽然补充剂不影响血糖指数,但与安慰剂组相比,镁组患者在干预后有更大的胰岛素抵抗(0.3±2.3μIU/mL vs. - 0.04±2.05,P = 0.04)。血清总胆固醇、甘油三酯、HDL、LDL和总胆固醇/HDL胆固醇比值没有显著变化。此外,镁不影响炎症、血清肌酐水平和血尿氮。然而,观察到微量白蛋白尿的边际下降(- 3.1 ± 2.2 mg/L vs. - 14 ± 9.9,P = 0.09)。

 

口服镁补充剂可略微改善糖尿病肾病患者的微量白蛋白尿,但会导致胰岛素抵抗增加。

 

原始出处:

 

Mehdi Sadeghian, Leila Azadbakht, et al., Oral Magnesium Supplementation Improved Lipid Profile but Increased Insulin Resistance in Patients With Diabetic Nephropathy: A Double-Blind Randomized Controlled Clinical Trial. Biol Trace Elem Res. 2020 Jan;193(1):23-35. doi: 10.1007/s12011-019-01687-6. Epub 2019 Mar 5.

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    2020-08-13 shanyongle
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    2020-12-29 sunylz
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    2020-09-25 bsmagic9140
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    2021-01-20 baoya
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    2020-06-16 misszhang

    谢谢MedSci提供最新的资讯

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