JACC:CT定义降低假体-患者不匹配发生频率和严重程度,并与TAVR术后不良结局无关

2017-08-21 xiangting MedSci原创

EOAi CT降低TAVR后患者PPM的发生频率和严重程度,与TAVR后1年死亡率无关。

这项研究旨在确定与常规超声心动图测量(EOAi TTE)相比,使用计算机断层扫描(EOAi CT)测量的左心室流出道,有效瓣口面积指数(EOAi )是否会重新分类假体-患者不匹配(PPM)。PPM不预测经导管主动脉瓣置换术(TAVR)后的死亡率。然而左心室流出道的EOAiCT是否会改善风险分层仍然未知。

对来自PARTNER II(主动脉导管导管II置入)试验S3i队列的总共765例TAVR患者进行了评估。使用连续性方程计算EOAi,并且从基线计算机断层扫描得出左心室流出道面积。传统超声心动图分类定义PPM:不存在(> 0.85cm2/m2),中等(≥0.65和≤0.85cm2/m2)或严重(≤0.65cm2/m2)。计算EOAi CT和EOAi TTE与1年结局的相关性。

EOA CT组PPM发生率为24%,EOAi TTE为45%。只有6%的PPM经EOAi CT分类为严重,而EOAi TTE则为9%。EOAi TTE,但不是EOAi CT,定义的PPM显示与左心室重量回归降低相关(p = 0.03 vs.p = 0.52)。PPM与1年的死亡或再住院没有任何关系。EOA CT与1年的小卒中相关(log-rank p = 0.04)和EOAi TTE与中风/短暂性脑缺血发作相关(log-rank p = 0.030)。此外,当排除轻度或更大的瓣膜返流患者后,PPM的存在与任何结果无关。

EOAi CT降低TAVR后患者PPM的发生频率和严重程度,与TAVR后1年死亡率无关。EOAi TTE,但不是EOAi CT,与左心室重量回归降低相关。

原始出处:

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    2018-07-30 hbwxf
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    2017-08-21 1dd8c52fm63(暂无匿称)

    学习学习,继续关注

    0

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    2017-08-21 雾夜芭蕾

    排除瓣膜轻度或更大的反流患者

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