Dig Dis Sci: 急性胰腺炎患者30天内再入院的危险因素和药物使用情况分析

2022-04-26 xuyihan MedSci原创

急性胰腺炎是多种病因导致胰酶在胰腺内被激活后引起胰腺组织自身消化、水肿、出血甚至坏死的炎症反应。

疼痛是急性胰腺炎(AP)的诊断标准之一,近一半的急性胰腺炎患者在使用阿片类药物处方后才能出院。酒精和香烟的使用是急性和复发性胰腺炎的危险因素,仅酒精就导致了高达 22%急性胰腺炎病例。此外,据报道,阿片类药物使用 (OUD) 的是慢性胰腺炎急性加重 30 天再入院的危险因素,本研究的目的是通过国家再入院数据库 (NRD) 利用大量人群来评估在急性胰腺炎背景下药物滥用患者的再入院率、医疗保健利用率和结果的差异。

这是一项回顾性队列研究,研究人员基于 2017 年美国国家再入院数据库中的 AP 和药物使用,对成年患者(联合酒精、阿片类药物、大麻、可卡因、镇静剂、其他兴奋剂、其他致幻剂、其他精神活性剂、吸入剂和杂项)的数据进行了收集。然后通过相关性分析估计了 30 天再入院率和 30 天再入院的预测因子。

 

在 25795 名符合条件的患者中,大多数为男性,大部分属于低收入人群,大部分居住在城市,并且 Charlson 合并症评分为 0 或 1。在 17265 名(66.9%)患者中使用各种止痛类药物组合最为常见,其次是 4691 名(18.2%)患者仅使用阿片类药物,3839 名(14.9%)患者仅使用大麻。共有 14.6% 的患者在出院后 30 天内因非选择性原因再次入院,出院后 1 周内再次入院的风险最高,为 5.2%。在再入院的十大原因中,大多数主要诊断与AP有关,占53.1%。与首次入院相比,再入院患者的急性心力衰竭、休克和住院死亡率显着更高。

 

本项研究证实再入院与 AP患者阿片类药物使用有关,这部分患者有较高发病率和院内死亡率,并导致美国医疗保健系统的重大经济负担。

原始出处:

Vivek Kumar. Et al. Characteristics of 30-Day All-Cause Hospital Readmissions Among Patients with Acute Pancreatitis and Substance Use. Digestive Diseases and Sciences.2022.

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    2022-07-19 smlt2008
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