ID Week:ω-3脂肪酸可降低HIV患者的甘油三酯

2016-10-29 MedSci MedSci原创

根据呈现在IDWeek 2016的研究数据,对于感染HIV、稳定ART的患者,每日高剂量ω-3脂肪酸,与安慰剂相比,可降低患者的甘油三酯和C-反应蛋白水平。塔夫斯大学医学中心的Gretchen Volpe博士说,心血管疾病在艾滋病病毒感染者中普遍存在。“艾滋病毒通过多种途径增加心血管疾病,包括血脂异常、慢性炎症和血管功能障碍,”她在这里的一个演讲中说。Volpe及其同事进行了她所说的最长的随机对照

根据呈现在IDWeek 2016的研究数据,对于感染HIV、稳定ART的患者,每日高剂量ω-3脂肪酸,与安慰剂相比,可降低患者的甘油三酯和C-反应蛋白水平。

塔夫斯大学医学中心的Gretchen Volpe博士说,心血管疾病在艾滋病病毒感染者中普遍存在。

“艾滋病毒通过多种途径增加心血管疾病,包括血脂异常、慢性炎症和血管功能障碍,”她在这里的一个演讲中说。

Volpe及其同事进行了她所说的最长的随机对照试验,评估高剂量的ω-3脂肪酸对HIV感染患者的血脂、炎症和血管功能的长期作用。

虽然之前的研究限定在24周以内,Volpe和同事们进行了一项超过24个月的研究。他们随机分配117例HIV感染、稳定ART的患者到每天4 g纯化的ω-3脂肪酸(n = 61)或安慰剂(n = 56)。患者的平均年龄为51岁,21%为女性,95%的患者处于病毒学抑制。

24个月后,ω-3脂肪酸组的甘油三酯及C反应蛋白降低福大超过安慰剂组。在ω-3脂肪酸组,甘油三酯下降68 mg/dL,安慰剂组下降22 mg/dL;而C-反应蛋白的差异分别是 –0.3 vs. +0.6 mg/L (P = .008)。

高密度脂蛋白胆固醇或肱动脉反应性,以及严重的不良事件,在两组之间无显着差异。

不过结果显示,长期补充ω-3脂肪酸能降低甘油三酯,可能减缓HIV阳性患者的慢性炎症。Volpe说,可能需要进一步的研究,超过24个月的治疗,对血管功能的真实效果。

“结果表明,补充ω-3脂肪酸的耐受性良好,不良反应较少。”

原始出处:

Volpe G, et al. Abstract 951. Presented at: IDWeek; Oct. 26-30, 2016; New Orleans.

Omega-3s decreased median triglycerides and CRP in HIV patients on ART.Healio.October 28, 2016


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