CJASN:慢性肾病患者生活方式干预或可改善心脏舒张功能

2013-09-04 晓静 编译 医学论坛网

8月22日在线发表于《美国肾脏病学会临床杂志(Clinical Journal of the American Society of Nephrology)的一项研究表明,慢性肾病(CKD)患者进行为期12个月的运动训练和生活方式干预与心肺适能、身体成分和心脏舒张功能较好具有相关性。该研究纳入90例3—4期进行运动负荷超声心动图的CKD患者,有83例通过筛查并进行了为期12个月的标准护理或

8月22日在线发表于《美国肾脏病学会临床杂志(Clinical Journal of the American Society of Nephrology)的一项研究表明,慢性肾病(CKD)患者进行为期12个月的运动训练和生活方式干预与心肺适能、身体成分和心脏舒张功能较好具有相关性。

该研究纳入90例3—4期进行运动负荷超声心动图的CKD患者,有83例通过筛查并进行了为期12个月的标准护理或生活方式干预。其中后者包括多专业的专家在CKD门诊的多学科指导医疗。还包括每周150分钟适度有氧和抗阻训练,和集体行为以及生活方式校正的健康教育。评估指标包括基线至12个月时CRF的改变、耗氧量峰值、左室功能、动脉僵硬度人体测量和生化试验指标等。

结果共72例患者完成随访,生活方式干预和对照组分别为36例,基线无差别。在进行筛查期间,10%的随机患者有亚临床心肌缺血,但他们都安全完成了研究。仅45%受试者(41%的生活方式干预组和47%对照组)在基线时实现了年龄预测的运动能力。在为期12个月的干预后,与接受常规护理组的最大需氧量增加了1%相比,生活方式干预组的最大需氧量显著增加了11%。干预组的峰值耗氧量增加(2.8 ± 0.7 mL/kg每分钟),而对照组的则有所降低((−0.3 ±.9 mL/kg每分钟,P =0.004).干预组有显著的体重减轻(−1.8 ±4.2 kg vs 0.7 ±3.7 kg; P =0.02),但血压和血脂水平无改变。

与对照组的心功能恶化相比,干预组的心室收缩功能保持并稳定,舒张功能有所改善(P =0.001),主动脉弹性改变较小(P =0.01)。

该研究的局限性在于未能将生活方式干预的个人成分分开以及缺乏药物剂量变化时的数据或运动量等。

原文查看

Howden EJ, Leano R, Petchey W, Coombes JS, Isbel NM, Marwick TH.Effects of Exercise and Lifestyle Intervention on Cardiovascular Function in CKD.Clin J Am Soc Nephrol. 2013 Aug 22



    

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2025770, encodeId=247a2025e7051, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Mon Apr 28 04:16:00 CST 2014, time=2014-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055924, encodeId=ab7a2055924bb, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Sun Nov 10 04:16:00 CST 2013, time=2013-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783223, encodeId=ac8f1e832236c, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Sat Jun 28 08:16:00 CST 2014, time=2014-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941235, encodeId=7c7b1941235d6, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Wed May 21 16:16:00 CST 2014, time=2014-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026146, encodeId=7f9f2026146b7, content=<a href='/topic/show?id=c2968658593' target=_blank style='color:#2F92EE;'>#舒张功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86585, encryptionId=c2968658593, topicName=舒张功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Oct 03 01:16:00 CST 2013, time=2013-10-03, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2025770, encodeId=247a2025e7051, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Mon Apr 28 04:16:00 CST 2014, time=2014-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055924, encodeId=ab7a2055924bb, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Sun Nov 10 04:16:00 CST 2013, time=2013-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783223, encodeId=ac8f1e832236c, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Sat Jun 28 08:16:00 CST 2014, time=2014-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941235, encodeId=7c7b1941235d6, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Wed May 21 16:16:00 CST 2014, time=2014-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026146, encodeId=7f9f2026146b7, content=<a href='/topic/show?id=c2968658593' target=_blank style='color:#2F92EE;'>#舒张功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86585, encryptionId=c2968658593, topicName=舒张功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Oct 03 01:16:00 CST 2013, time=2013-10-03, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2025770, encodeId=247a2025e7051, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Mon Apr 28 04:16:00 CST 2014, time=2014-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055924, encodeId=ab7a2055924bb, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Sun Nov 10 04:16:00 CST 2013, time=2013-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783223, encodeId=ac8f1e832236c, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Sat Jun 28 08:16:00 CST 2014, time=2014-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941235, encodeId=7c7b1941235d6, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Wed May 21 16:16:00 CST 2014, time=2014-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026146, encodeId=7f9f2026146b7, content=<a href='/topic/show?id=c2968658593' target=_blank style='color:#2F92EE;'>#舒张功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86585, encryptionId=c2968658593, topicName=舒张功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Oct 03 01:16:00 CST 2013, time=2013-10-03, status=1, ipAttribution=)]
    2014-06-28 ay2000fy
  4. [GetPortalCommentsPageByObjectIdResponse(id=2025770, encodeId=247a2025e7051, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Mon Apr 28 04:16:00 CST 2014, time=2014-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055924, encodeId=ab7a2055924bb, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Sun Nov 10 04:16:00 CST 2013, time=2013-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783223, encodeId=ac8f1e832236c, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Sat Jun 28 08:16:00 CST 2014, time=2014-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941235, encodeId=7c7b1941235d6, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Wed May 21 16:16:00 CST 2014, time=2014-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026146, encodeId=7f9f2026146b7, content=<a href='/topic/show?id=c2968658593' target=_blank style='color:#2F92EE;'>#舒张功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86585, encryptionId=c2968658593, topicName=舒张功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Oct 03 01:16:00 CST 2013, time=2013-10-03, status=1, ipAttribution=)]
    2014-05-21 chenhongpeng
  5. [GetPortalCommentsPageByObjectIdResponse(id=2025770, encodeId=247a2025e7051, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Mon Apr 28 04:16:00 CST 2014, time=2014-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055924, encodeId=ab7a2055924bb, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Sun Nov 10 04:16:00 CST 2013, time=2013-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783223, encodeId=ac8f1e832236c, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Sat Jun 28 08:16:00 CST 2014, time=2014-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941235, encodeId=7c7b1941235d6, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Wed May 21 16:16:00 CST 2014, time=2014-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026146, encodeId=7f9f2026146b7, content=<a href='/topic/show?id=c2968658593' target=_blank style='color:#2F92EE;'>#舒张功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86585, encryptionId=c2968658593, topicName=舒张功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Oct 03 01:16:00 CST 2013, time=2013-10-03, status=1, ipAttribution=)]
    2013-10-03 yahu

相关资讯

JASN:肾脏病药物可能会导致动脉硬化

  近日研究人员发现,磷结合剂可以降低慢性肾病患者(CKD)血清磷水平,但同时也可能会增加血管钙化的发生。     美国丹佛肾脏病学博士Geoffrey Block及其同事对三种不同磷结合剂进行了研究,研究中服用任一磷结合剂的患者,其血磷水平均较基线处显著下降,下降幅度与安慰剂组相比有显著差异(P=0.03)。     他们在美国肾脏学学会杂志上在线报道,与服用安慰剂患