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Stroke ：CT灌注中大脑中动脉深部供血区通透性预测脑梗死后出血转化的价值。

2017-08-08 shaosai MedSci原创

急性脑梗死大脑中动脉CT灌注
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CT灌注（CTP）中的通透性（PS）反映了血脑屏障通透性，与出血转化（HT）有关。大脑中动脉（MCA）深部供血区的HT可在大血管闭塞再通后出现。本研究旨在确定HT和MCA深部供血区PS的关系，并将结果发表在Stroke上。

CT灌注（CTP）中的通透性（PS）反映了血脑屏障通透性，与出血转化（HT）有关。大脑中动脉（MCA）深部供血区的HT可在大血管闭塞再通后出现。本研究旨在确定HT和MCA深部供血区PS的关系，并将结果发表在Stroke上。

本研究回顾性分析了70例颈内动脉末端或MCA的M1段闭塞并有急性缺血性脑卒中的患者。所有患者在发病后6小时之内进行了CTP。CTP数据经后处理后生成各种灌注参数。确定MCA深部供血区PS出现的危险因子。利用ROC曲线计算能够预测MCA深部供血区HT的最佳PS阈值。

结果为，升高的PS与MCA深部供血区的HT相关。经过对年龄、性别、发病到CTP扫描的时间和基线NIHSS后，侧支循环功能差(OR=7.8； 95% CI：1.67-37.14； P=0.009)和MCA-M1近端闭塞(OR=4.12； 95% CI：1.03-16.52； P=0.045)独立地与MCA深部供血区PS相关。相对PS最能准确地预测MCA深部供血区HT的发生(AUC=0.94； 阈值为2.89)。

本研究表明，大脑大血管近端闭塞再通治疗后，升高的PS能够预测MCA深部供血区的HT的发生。MCA-M1近端和颈内动脉末端闭塞加上侧支循环较差会加重MCA深部供血区的PS。

原始出处：


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encodeId=585823199ef8, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Aug 10 00:49:04 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231974, encodeId=c5562319e489, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Aug 09 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    2017-10-31 楚钟

    #大脑中动脉#

    0

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    2018-03-31 zhmscau

    #通透性#

    0

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22:22:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231918, encodeId=88b023191861, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Aug 09 19:43:39 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-30 周周人

    学习..

    0

  4. 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22:22:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231918, encodeId=88b023191861, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Aug 09 19:43:39 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-14 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  5. 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22:22:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231918, encodeId=88b023191861, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Aug 09 19:43:39 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-13 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  6. 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22:22:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231918, encodeId=88b023191861, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Aug 09 19:43:39 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-11 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Aug 14 18:30:28 CST 2017, time=2017-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233302, encodeId=13b523330250, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Aug 13 23:39:34 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232631, encodeId=18e423263136, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, 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encodeId=585823199ef8, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Aug 10 00:49:04 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231974, encodeId=c5562319e489, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Aug 09 22:22:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231918, encodeId=88b023191861, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Aug 09 19:43:39 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-10 karmond

    #脑梗#

    0

  8. 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22:22:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231918, encodeId=88b023191861, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Aug 09 19:43:39 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-10 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  9. 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22:22:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231918, encodeId=88b023191861, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Aug 09 19:43:39 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-09 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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    2017-08-09 虈亣靌

    很好，不错，以后会多学习

    0

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