JAHA:低流量重度主动脉瓣狭窄患者接受TAVR的死亡率预测因子和结局

2018-04-15 xiangting MedSci原创

LF是主动脉瓣狭窄人群中的常见表现,与LV射血分数或平均压力梯度相反,是全因死亡率和心血管死亡率的独立预测因子。

左心室(LV)射血分数受损是主动脉瓣狭窄患者的常见表现,并可作为经导管主动脉瓣置换(TAVR)术后发病率和死亡率的预测指标。然而,关于LV功能最准确指标的数据存在冲突。这项研究旨在探讨LV射血分数、平均压力梯度和每搏输出量指数对TAVR患者预后的影响。

TAVR患者主要分为正常血流量(NF ;每搏量指数> 35mL/m2)和低流量(LF ;每搏输出量指数≤35mL/m2)。随后,患者被分为5组:"NF-高梯度","NF-低梯度"(NF-LG),"LF-高梯度","异常LF-LG"和"经典LF-LG"。 3年死亡率是主要终点。在1600例患者中,789例(49.3%)被诊断为LF,其特征为30天(P = 0.041)和3年(P <0.001)死亡率更高。LF是全因死亡率(危险比1.29; 95%可信区间1.03-1.62; P = 0.03)和心血管死亡率(危险比1.37; 95%置信区间1.06-1.77; P = 0.016)的独立预测因子。平均压力梯度和LV射血分数都不是死亡率的独立预测因子。与NF -高梯度(24.8%)和NF-LG(27.9%)(P = 0.001)相比,异常LF-LG(35.0%)、经典LF-LG(35.1%)和LF-高梯度(38.1%)患者的3年全因死亡率较高。然而,存活的患者无论主动脉瓣狭窄如何,症状改善类似。

LF是主动脉瓣狭窄人群中的常见表现,与LV射血分数或平均压力梯度相反,是全因死亡率和心血管死亡率的独立预测因子。尽管长期死亡率升高,手术成功率高和功能改善良好,支持LF重度主动脉瓣狭窄患者接受经导管主动脉瓣置换术

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    2018-04-17 zhaohui6731
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createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 15 16:31:19 CST 2018, time=2018-04-15, status=1, ipAttribution=)]
    2018-04-15 虈亣靌

    嘿嘿.真是让人耳目一新.感觉望尘莫及似的.学习了

    0

  8. 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    2018-04-15 有备才能无患

    左心室(LV)射血分数受损是主动脉瓣狭窄患者的常见表现.并可作为经导管主动脉瓣置换(TAVR)术后发病率和死亡率的预测指标.然而.关于LV功能最准确指标的数据存在冲突.这项研究旨在探讨LV射血分数.平均压力梯度和每搏输出量指数对TAVR患者预后的影响

    0

  9. 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createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 15 16:31:19 CST 2018, time=2018-04-15, status=1, ipAttribution=)]
    2018-04-15 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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