JCEM:肢端肥大患者的糖尿病及高血压患病率如何

2018-04-03 MedSci MedSci原创

大家都知道糖尿病和高血压是肢端肥大症的常见并发症,而近日在JCEM上发表的一篇文章则旨在研究大型肢端肥大症患者中诊断时和多模式治疗后糖尿病和高血压的病程。

大家都知道糖尿病高血压是肢端肥大症的常见并发症,而近日在JCEM上发表的一篇文章则旨在研究大型肢端肥大症患者中诊断时和多模式治疗后糖尿病高血压的病程。

研究人员进行了一项回顾性的研究,共纳入522例根据之前已经确定的方案治疗的肢端肥大患者,主要的测量结果是糖尿病和高血压的发病率及与肢端肥大症控制的生化指标的关系。

该队列根据最后一次就诊的疾病状态进行分层:a)手术缓解(n = 122),b)药理学控制(n = 92),c)活动性疾病(n = 148),d)IGF-1不一致性(n = 64)和e)GH不一致(n = 96)。在诊断肢端肥大时糖尿病和高血压的患病率分别为30%和37%,最后一次访视时并未改变(30.6%和38%)。这两种合并症的发生率在诊断和最后访视时比普通人群更普遍。在获得手术缓解的患者中,最后一次就诊的糖尿病发生率低于持续存在活动性疾病的患者(25% vs 40%,p = 0.01)。经多变量分析,糖尿病与诊断时> 2×ULN的IGF-1、持续存在的活动性肢端肥大、最后就诊时伴发高血压、伴发大腺瘤及女性有关。

上述研究结果表明在管理这些患者时采用整体方法的重要性,不仅仅关注GH及IGF-1的水平,还要注重及时诊断和具体治疗每种并发症。

原始出处:

Baldomero González.et al. Persistence of Diabetes and Hypertension after Multimodal Treatment of Acromegaly. J Clin Endocrinol Metab. 2018.

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    2018-09-14 achengzhao
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Fri Apr 06 06:58:44 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303094, encodeId=0aec303094a2, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Apr 05 21:34:43 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250534, encodeId=4806125053482, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Thu Apr 05 10:43:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302702, encodeId=8c9e302e026a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Wed Apr 04 13:59:42 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302444, encodeId=7b6d302444e1, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Tue Apr 03 20:47:53 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-07-15 smallant2015
  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Fri Apr 06 06:58:44 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303094, encodeId=0aec303094a2, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Apr 05 21:34:43 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250534, encodeId=4806125053482, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Thu Apr 05 10:43:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302702, encodeId=8c9e302e026a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Wed Apr 04 13:59:42 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302444, encodeId=7b6d302444e1, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Tue Apr 03 20:47:53 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-04-07 yfjms

    学习

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Fri Apr 06 06:58:44 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303094, encodeId=0aec303094a2, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Apr 05 21:34:43 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250534, encodeId=4806125053482, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Thu Apr 05 10:43:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302702, encodeId=8c9e302e026a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Wed Apr 04 13:59:42 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302444, encodeId=7b6d302444e1, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Tue Apr 03 20:47:53 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-04-06 雅文博武

    学习了很多先进的医学知识

    0

  7. 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encodeId=7b6d302444e1, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Tue Apr 03 20:47:53 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-04-05 惠映实验室

    学习了.谢谢分享.

    0

  8. 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encodeId=7b6d302444e1, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Tue Apr 03 20:47:53 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-04-05 xinmeili
  9. 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    2018-04-04 海之蓝

    学习

    0

  10. 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    2018-04-03 orangesking

    0

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