J Laryngol Otol:内皮细胞特异性分子-1和穿透素-3在先天性突发感官听力损失中的血清水平研究

2018-11-06 AlexYang MedSci原创

最近,有研究人员在患有先天性感官听力损失的患者中评估了内皮细胞特异性分子-1(ESM-1)和穿透素-3(PTX-3)的血清水平,并且还比较了所有患者的治疗前后的水平。研究总共包括了108名参与者:51名患有先天性突发感官听力损失,57名为对照。为了分析ESM-1和PTX-3水平,研究人员在患有先天性突发感官听力损失患者治疗前后3个月对患者进行血液采集,并且在对照组中只采集一次。治疗的响应在治疗开始

最近,有研究人员在患有先天性感官听力损失的患者中评估了内皮细胞特异性分子-1(ESM-1)和穿透素-3(PTX-3)的血清水平,并且还比较了所有患者的治疗前后的水平。

研究总共包括了108名参与者:51名患有先天性突发感官听力损失,57名为对照。为了分析ESM-1和PTX-3水平,研究人员在患有先天性突发感官听力损失患者治疗前后3个月对患者进行血液采集,并且在对照组中只采集一次。治疗的响应在治疗开始后3个月利用纯音听力测定进行评估,并且将患者分成治疗响应组和治疗不响应组。研究发现,ESM-1的血清水平在先天性感官听力损失组中要比对照组显著更高,而PTX-3则没有显著的差异。在治疗响应组和非响应组中,ESM-1和PTX-3水平在治疗前后没有显出的差异。

最后,研究人员指出,他们是首次在先天性感官听力损失中调查了ESM-1和PTX-3水平。血清EMS-1水平的增加能够确定在先天性感官听力损失病理中内皮功能障碍的参与,并且也可能与血管损伤有关。

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    2018-11-08 ysjykql
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    2018-11-08 huirong

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