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Eur Uro：端粒长度相关的遗传变异与肾细胞癌风险增加有关。

2017-08-10 MedSci MedSci原创

肾细胞癌端粒白细胞GRSGWAS
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在以往的一些研究中，外周血白细胞的相对端粒长度被认为是肾细胞癌（RCC）风险的潜在生物标志物。为了确定这种关系，研究者进行了更深入的研究。

在以往的一些研究中，外周血白细胞的相对端粒长度被认为是肾细胞癌（RCC）风险的潜在生物标志物。为了确定这种关系，研究者进行了更深入的研究。为了使早期调查结果不受时间效应偏倚和因果颠倒偏倚的影响，研究者使用了孟德尔随机化方法分析了与白细胞端粒长度相关的遗传变异，并进一步确定端粒长度和肾细胞癌（RCC）之间的关系。他们聚集了来自10784例共有9种端粒长度相关变异患者的基因型和来自6项RCC全基因组关联研究（GWAS）的20406例无癌对照，通过加权遗传风险评分（GRS）预测白细胞端粒长度。将GRS和RCC风险的比值比（OR）计算到个人全基因组关联研究（GWAS）数据集中，并结合了荟萃分析。结果是较长的基因推断端粒长度与肾细胞癌风险增加相关（OR =2.07 每预测增加一千碱基对，95%置信区间[CI]： = 1.70-2.53，P＜0.0001  ）。作为一个敏感性分析，在对端粒长度进行加权遗传风险评分中，研究者排除了连锁不平衡（R2> 0.5）以及全基因组关联研究确定的两种RCC风险变异（rs10936599和rs9420907）。排除后，GRS和RCC风险之间的关联仍

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06:55:09 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232654, encodeId=4d7223265427, content=端粒长度相关的遗传变异与肾细胞癌风险增加有, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sat Aug 12 00:29:27 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-09-04 qingting

    #细胞癌#

    0

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    2017-11-27 马龙

    #肾细胞癌风险#

    0

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06:55:09 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232654, encodeId=4d7223265427, content=端粒长度相关的遗传变异与肾细胞癌风险增加有, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sat Aug 12 00:29:27 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-12-31 sjq027

    #癌风险#

    0

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06:55:09 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232654, encodeId=4d7223265427, content=端粒长度相关的遗传变异与肾细胞癌风险增加有, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sat Aug 12 00:29:27 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-16 jacob9231

    学习了谢谢分享

    0

  5. 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06:55:09 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232654, encodeId=4d7223265427, content=端粒长度相关的遗传变异与肾细胞癌风险增加有, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sat Aug 12 00:29:27 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 jacob9231

    学习了谢谢分享

    0

  6. 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06:55:09 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232654, encodeId=4d7223265427, content=端粒长度相关的遗传变异与肾细胞癌风险增加有, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sat Aug 12 00:29:27 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 doctor-chen9582

    #端粒长度#

    0

  7. 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style='color:#2F92EE;'>#端粒长度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75696, encryptionId=8d20e5696c5, topicName=端粒长度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8fc0211, createdName=doctor-chen9582, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342421, encodeId=2494134242194, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377185, encodeId=c06c13e71858a, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232725, encodeId=bca6232e25eb, content=学习了不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/25/50686bfef7f9754dfa5d0ccec059c9de.jpg, createdBy=8d992083353, createdName=139****9672, createdTime=Sat Aug 12 06:55:09 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232654, encodeId=4d7223265427, content=端粒长度相关的遗传变异与肾细胞癌风险增加有, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sat Aug 12 00:29:27 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 12498dabm77暂无昵称

    #变异#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1978532, encodeId=d5af19e853258, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Mon Sep 04 10:47:00 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809013, encodeId=7d2c18090133e, content=<a href='/topic/show?id=50118264899' target=_blank style='color:#2F92EE;'>#肾细胞癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82648, encryptionId=50118264899, topicName=肾细胞癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba58436, createdName=马龙, createdTime=Mon Nov 27 20:47:00 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061646, encodeId=a7ae206164631, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Dec 31 02:47:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234137, encodeId=bd2323413e42, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM66WRRAmeqIVSnDN88DpaJfEWzRZxg4yBbiaBmMRwcvViaA2C0sE0Ts3Lic24JSSI4YffujDtpnm0GTHpuiao9TytmNArrcYESnSXY/0, createdBy=7938104912, createdName=jacob9231, createdTime=Wed Aug 16 18:20:31 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232969, encodeId=ce47232969fd, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM66WRRAmeqIVSnDN88DpaJfEWzRZxg4yBbiaBmMRwcvViaA2C0sE0Ts3Lic24JSSI4YffujDtpnm0GTHpuiao9TytmNArrcYESnSXY/0, createdBy=7938104912, createdName=jacob9231, createdTime=Sat Aug 12 23:06:57 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288628, encodeId=2841128862807, content=<a href='/topic/show?id=8d20e5696c5' target=_blank style='color:#2F92EE;'>#端粒长度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75696, encryptionId=8d20e5696c5, topicName=端粒长度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8fc0211, createdName=doctor-chen9582, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342421, encodeId=2494134242194, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377185, encodeId=c06c13e71858a, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232725, encodeId=bca6232e25eb, content=学习了不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/25/50686bfef7f9754dfa5d0ccec059c9de.jpg, createdBy=8d992083353, createdName=139****9672, createdTime=Sat Aug 12 06:55:09 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232654, encodeId=4d7223265427, content=端粒长度相关的遗传变异与肾细胞癌风险增加有, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sat Aug 12 00:29:27 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 weihongyv

    #遗传变异#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1978532, encodeId=d5af19e853258, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Mon Sep 04 10:47:00 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809013, encodeId=7d2c18090133e, content=<a href='/topic/show?id=50118264899' target=_blank style='color:#2F92EE;'>#肾细胞癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82648, encryptionId=50118264899, topicName=肾细胞癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba58436, createdName=马龙, createdTime=Mon Nov 27 20:47:00 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061646, encodeId=a7ae206164631, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Dec 31 02:47:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234137, encodeId=bd2323413e42, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM66WRRAmeqIVSnDN88DpaJfEWzRZxg4yBbiaBmMRwcvViaA2C0sE0Ts3Lic24JSSI4YffujDtpnm0GTHpuiao9TytmNArrcYESnSXY/0, createdBy=7938104912, createdName=jacob9231, createdTime=Wed Aug 16 18:20:31 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232969, encodeId=ce47232969fd, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM66WRRAmeqIVSnDN88DpaJfEWzRZxg4yBbiaBmMRwcvViaA2C0sE0Ts3Lic24JSSI4YffujDtpnm0GTHpuiao9TytmNArrcYESnSXY/0, createdBy=7938104912, createdName=jacob9231, createdTime=Sat Aug 12 23:06:57 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288628, encodeId=2841128862807, content=<a href='/topic/show?id=8d20e5696c5' target=_blank style='color:#2F92EE;'>#端粒长度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75696, encryptionId=8d20e5696c5, topicName=端粒长度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8fc0211, createdName=doctor-chen9582, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342421, encodeId=2494134242194, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377185, encodeId=c06c13e71858a, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232725, encodeId=bca6232e25eb, content=学习了不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/25/50686bfef7f9754dfa5d0ccec059c9de.jpg, createdBy=8d992083353, createdName=139****9672, createdTime=Sat Aug 12 06:55:09 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232654, encodeId=4d7223265427, content=端粒长度相关的遗传变异与肾细胞癌风险增加有, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sat Aug 12 00:29:27 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 139****9672

    学习了不错啊

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1978532, encodeId=d5af19e853258, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Mon Sep 04 10:47:00 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809013, encodeId=7d2c18090133e, content=<a href='/topic/show?id=50118264899' target=_blank style='color:#2F92EE;'>#肾细胞癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82648, encryptionId=50118264899, topicName=肾细胞癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba58436, createdName=马龙, createdTime=Mon Nov 27 20:47:00 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061646, encodeId=a7ae206164631, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Dec 31 02:47:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234137, encodeId=bd2323413e42, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM66WRRAmeqIVSnDN88DpaJfEWzRZxg4yBbiaBmMRwcvViaA2C0sE0Ts3Lic24JSSI4YffujDtpnm0GTHpuiao9TytmNArrcYESnSXY/0, createdBy=7938104912, createdName=jacob9231, createdTime=Wed Aug 16 18:20:31 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232969, encodeId=ce47232969fd, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM66WRRAmeqIVSnDN88DpaJfEWzRZxg4yBbiaBmMRwcvViaA2C0sE0Ts3Lic24JSSI4YffujDtpnm0GTHpuiao9TytmNArrcYESnSXY/0, createdBy=7938104912, createdName=jacob9231, createdTime=Sat Aug 12 23:06:57 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288628, encodeId=2841128862807, content=<a href='/topic/show?id=8d20e5696c5' target=_blank style='color:#2F92EE;'>#端粒长度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75696, encryptionId=8d20e5696c5, topicName=端粒长度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8fc0211, createdName=doctor-chen9582, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342421, encodeId=2494134242194, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377185, encodeId=c06c13e71858a, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Sat Aug 12 13:47:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232725, encodeId=bca6232e25eb, content=学习了不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/25/50686bfef7f9754dfa5d0ccec059c9de.jpg, createdBy=8d992083353, createdName=139****9672, createdTime=Sat Aug 12 06:55:09 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232654, encodeId=4d7223265427, content=端粒长度相关的遗传变异与肾细胞癌风险增加有, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sat Aug 12 00:29:27 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 ann y

    端粒长度相关的遗传变异与肾细胞癌风险增加有

    0

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JAMA Oncology：高风险肾细胞癌肾切除术后Girentuximab辅助治疗

Girentuximab是一种结合了碳酸酐酶Ⅸ的嵌合式单克隆抗体，碳酸酐酶Ⅸ是肾透明细胞癌（ccRCC）细胞表明广泛表达的糖蛋白。在Ⅱ期研究中已验证了其安全性和活性，从而推进了其作为高风险ccRCC辅助治疗药物的进一步研究。JAMA Oncology近期发表了一篇文章，评估了Girentuximab辅助治疗对局部完全切除的高风险ccRCC患者无病生存（DFS）以及总生存（OS）的影响。

Sci Rep：较低的平均血小板体积可以预测肾细胞癌不良预后

之前的研究发现，改变的的平均血小板体积（MPV）在几种恶性肿瘤中存在。值得注意的是，MPV在肾细胞癌（RCC）中预后评估的价值还没有达成共识。最近，有研究人员调查了MPV值作为一个RCC预后因子的可能性。该回顾性的研究招募了在2009年1月到2009年12月的306名连续的RCC病人。研究人员对MPV和临床病理学特性的关系进行了分析，并利用卡普兰-梅尔分析方法和Cox回归评估了MPV的预后影响。研

Lab Invest： 乳突状肾细胞癌趋化素、IL-8和CXCL16可以促进单核细胞募集和分化成泡沫巨噬细胞

乳突状肾细胞癌（pRCC）是肾细胞癌的第二大常见类型。唯一的有效治疗Prcc的方法为根治性外科切除术。如果疾病发生扩散，化疗或者放疗都将不在产生治疗效果，因此对Prcc更进一步的研究非常重要。从组织病理上来说，pRCC是通过乳突的生长模式，即泡沫细胞表型的巨噬细胞焦点聚集。在其他类型的癌症中，在癌症生长和进展时，肿瘤相关的巨噬细胞的清楚的角色已经报道。尽管泡沫状巨噬细胞的出现是pRCC肿瘤的一个组

Oncogene：PDZK-1可以通过抑制SHP-1的磷酸化抑制肾细胞癌的发生和发展

肾细胞癌（RCC）是最具有侵略性泌尿外科癌症之一，然而，RCC致癌作用的的机制到目前为止仍旧不清楚。最近，研究人员通过利用基因表达分析和功能聚类发现，包含PDZ结构域蛋白1（PDZK1）在人类透明细胞肾细胞癌（ccRCC）中表达下调，该现象在一些相互独立的公共ccRCC数据库中同样得到了鉴证。另外，通过在ccRCC细胞系中PDZK1的超表达和敲除，研究人员阐释了PDZK1可以抑制细胞增殖、细胞周期

JCO：Nivolumab联合Ipilimumab治疗转移性肾细胞癌

免疫检查点抑制剂联合治疗与单药治疗相比具有更强的抗肿瘤活性。Ⅰ期Checkmate 016研究主要评估Nivolumab联合Ipilimumab以及Nivolumab加一种酪氨酸激酶抑制剂治疗转移性肾细胞癌（mRCC）的有效性及安全性。JCO近期发表了一篇文章，报道了Nivolumab联合Ipilimumab组的安全性及有效性结果。

JCO：Nivolumab联合ipilimumab——转移性肾细胞癌患者的新福音？

如今越来越多的研究表明与单一疗法相比，联合免疫抑制剂的联合疗法表现出更强的抗肿瘤活性，如黑色素瘤的治疗。开放、平行对照、剂量递增、 I 期阶段的CheckMate研究评估了nivolumab加ipilimumab联合治疗、nivolumab加酪氨酸激酶抑制剂在转移性肾细胞癌中（mRCC）的安全性和疗效。nivolumab联合ipilimumab治疗的安全性和有效性如下文所示。