JASN ASN:研究发现咖啡因摄入可延长肾病患者的寿命!

2017-11-04 sunshine2015 来宝网

根据将于10月31日至11月5日在洛杉矶新奥尔良Ernest N. Morial会议中心进行并发表在ASN肾脏周的一项研究,咖啡因的摄入可能会延长慢性肾病(CKD)患者的生命。

咖啡因可能帮助肾病患者活得更久】根据将于10月31日至11月5日在洛杉矶新奥尔良Ernest N. Morial会议中心进行并发表在ASN肾脏周的一项研究,咖啡因的摄入可能会延长慢性肾病(CKD)患者的生命

咖啡消费与一般人口的寿命有关。为了看看这是否适用于患有CKD的个人,米格尔·比戈特维埃拉,MD(炫酷HOSPITALAR葡京北,葡萄牙),和他的同事研究咖啡因摄入量与死亡率之间的关联,在2328名CKD患者中进行了前瞻性队列研究,使用了1999 - 2010年间的国家健康和营养调查(NHANES)数据。

该研究小组发现咖啡因与全因死亡率呈剂量依赖性负相关。与最低四分位数的咖啡因摄入量相比,第二,三,四分位数分别将死亡率降低了12%,22%和24%。

“我们的研究显示,慢性肾脏病患者中的咖啡因消费对死亡的剂量依赖性的保护作用。该关联性是独立的潜在混杂因素,包括年龄,性别,种族,家庭年收入,受教育程度,估计肾小球滤过率,白蛋白/肌酐比值,高血压,吸烟状况,血脂异常,体重指数,既往心血管事件和饮食:酒精,碳水化合物,多不饱和脂肪酸和纤维的消耗,“比奥特·维埃拉博士说。

“这些结果表明,建议CKD患者喝更多的咖啡因可能会降低他们的死亡率,这将是一个简单的,临床上有益的和便宜的选择,尽管这个好处应该在随机临床试验中得到理想的证实。 Bigotte Vieira博士强调,这项观察性研究不能证明咖啡因能降低慢性肾脏病患者的死亡风险,但仅仅表明了这种保护作用的可能性。

原始出处:

Maarten M. Brandt, Claartje A. Meddens, Laura Louzao-Martinez, et al. Chromatin Conformation Links Distal Target Genes to CKD Loci. JASN ASN.2016080875; published ahead of print November 1, 2017, doi:10.1681/ASN.2016080875.

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