JAHA:动脉硬化程度的种族差异主要是由血压水平决定的

2017-06-22 xing.T MedSci原创

由此可见,cf-PWV的种族差异主要是由于平均动脉压和年龄的差异所致,尽管他们不能完全解释最高cf-PWV值的女性种族和cf-PWV之间的相关性。这表明克服衰老对血管系统影响的治疗方法应该集中在血压控制上,尤其是在黑人人群中。

黑人患高血压血管硬化的风险较高。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在调查种族与主动脉僵硬之间的关系是否可以通过主要危险因素的差异来解释。

研究人员分析了11472例成人(平均年龄为51.9±8.9;女性占53.8%),其中自我报告的白种人(n=6173),黄种人(n=3364)或黑种人(n=1935)。研究人员测量了这些参与者的颈动脉股动脉脉搏波传导速度(cf-PWV)以及临床和人体测量参数。

研究人员发现相比于白种人和黄种人,黑人cf-PWV较高(男性:白种人,9.63±1.81;黄种人,9.63±1.88;黑人,9.98±1.99;女性:白种人,8.84±1.64;黄种人,9.02±1.68;黑人,9.34±1.91;P<0.05)。不过,调整年龄、平均动脉压、心率、腰围、空腹血糖和肾小球滤过率后差异消失(男性:白种人,9.68±1.54;黄种人,9.68±1.50;黑人,9.73±1.52;女性:白种人,8.93±1.32;黄种人,8.98±1.29;黑人,9.02±1.32;P<0.05)。种族与动脉僵硬度之间的相关性在最高四分位数cf-PWV范围的黄种人和黑人女性中较为显著,即使在控制变量后。在调整后的种族群体中年龄相关的cf-PWV增加没有差异,多元线性回归分析证实了年龄和平均动脉压对cf-PWV的强烈影响。

由此可见,cf-PWV的种族差异主要是由于平均动脉压和年龄的差异所致,尽管他们不能完全解释最高cf-PWV值的女性种族和cf-PWV之间的相关性。这表明克服衰老对血管系统影响的治疗方法应该集中在血压控制上,尤其是在黑人人群中。

原始出处:

Marcelo P. Baldo,et al. Racial Differences in Arterial Stiffness are Mainly Determined by Blood Pressure Levels: Results From the ELSA‐Brasil Study.JAHA.2017. https://doi.org/10.1161/JAHA.117.005477

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    2017-07-06 王晓霞

    学习

    0

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    2017-06-29 王晓霞

    学习

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Sat Jun 24 03:28:20 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214491, encodeId=546421449165, content=学习了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Fri Jun 23 22:33:22 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214336, encodeId=5ebe2143365d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Fri Jun 23 10:15:07 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-28 王晓霞

    学习了

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Sat Jun 24 03:28:20 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214491, encodeId=546421449165, content=学习了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Fri Jun 23 22:33:22 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214336, encodeId=5ebe2143365d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Fri Jun 23 10:15:07 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-26 王晓霞

    学习了

    0

  6. 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  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Fri Jun 23 10:15:07 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-24 zhaohui6731
  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Fri Jun 23 10:15:07 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-24 hfuym10906

    。。。。。。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1984263, encodeId=fae719842638f, content=<a href='/topic/show?id=4af8889533b' target=_blank style='color:#2F92EE;'>#血压水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88953, encryptionId=4af8889533b, topicName=血压水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Sun May 06 16:31:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219066, encodeId=29942190665b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/7e2c04a7e58b6065a1392efd799c6a6b.jpg, createdBy=de482077642, createdName=王晓霞, createdTime=Thu Jul 06 07:53:23 CST 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Fri Jun 23 10:15:07 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-23 林3301

    学习了解了

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Fri Jun 23 10:15:07 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-23 榄枷檬

    谢谢分享

    0

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在血液透析患者中,AASI在评估动脉硬化程度上的价值有限,无论是单独使用或添加到PP。该研究结果表明,在今后的实践和研究中,该指标不应作为透析患者动脉硬化程度的评价指标。

JAHA:循环中PCSK9水平与动脉硬化相关吗?

在布里西盖拉心脏研究中,循环PCSK9水平是动脉硬化显著相关,并且独立于性别以及女性的绝经状态。

Hypertension:肾素-血管紧张素-醛固酮系统不参与急性和长期暴露于高海拔引起的动脉硬化!

总之,低压缺氧的急性暴露会导致动脉硬化和减少心内膜下心肌氧供需指数。此外,肾素-血管紧张素-醛固酮系统在这些血流动力学改变中似乎不起任何重要作用。