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病例-队列研究（case-cohort study）介绍

2014-05-26 MedSci MedSci原创

临床研究
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病例-队列研究（case-cohort study）  又称病例参比式研究（case-base reference study），也是一种队列研究与病例对照研究结合的设计形式。队列研究开始时，在队列中按一定比例随机抽样选出一个有代表性的样本作为对照组，观察结束时，队列中出现的所研究疾病的全部病例作为病例组，与上述随机对照组进行比较。在流行病学研究中常常会遇到这样的情况:在一个大样本队列中

病例-队列研究（case-cohort study）  又称病例参比式研究（case-base reference study），也是一种队列研究与病例对照研究结合的设计形式。队列研究开始时，在队列中按一定比例随机抽样选出一个有代表性的样本作为对照组，观察结束时，队列中出现的所研究疾病的全部病例作为病例组，与上述随机对照组进行比较。在流行病学研究中常常会遇到这样的情况:在一个大样本队列中,随访一段时间后只能得到少量病人,其他大多数对象只能得到截尾(censored)观察结果,这时如果要获得所有对象的协变量资料作统计分析,则需花费大量的资源。为此,Prentice RL在1986年提出了一种新的设计方法--病例队列研究(case-cohort  study),该设计仅收集全部研究对象(全队列)中的一个随机样本(子队列, subcohort)和所有发病者(不论是否在子队列内)的协变量资料进行分析,因此极具研究效率.该方法吸取了病例对照研究与队列研究的许多优点,目前被广泛应用于医学研究中.1 病例队列研究的设计原理：病例队列研究是将队列设计和病例对照研究设计相互交叉,融合

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  1. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2015-02-03 20142060

    以前没有听说过，很好！新知识

    0

  2. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2015-03-07 guojianrong

    #cohort#

    0

  3. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2014-07-05 charl1234567

    #case#

    0

  4. 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createdName=jet747, createdTime=Fri Oct 17 15:42:00 CST 2014, time=2014-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10691, encodeId=79ad106915c, content=新内容、新视野, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKHTxibnTFDibsIc9IbicSoNvDavBYy3n5QqAZr2cxfMMUgeOEeuxAqGK9L29c7fumcbxNNVib0TZaJEA/132, createdBy=1cdb95091, createdName=zgarycn, createdTime=Sun Jul 27 10:06:00 CST 2014, time=2014-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10142, encodeId=f91c10142b4, content=太有用了！！值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIT1K5HVp6e14M3lDgTeribfs0NS0dVZvl53ibWm9N1TCxRBM0XgpicgHeORWZmrib5TEIZLr8mvy9Tvw/132, createdBy=1026104176, createdName=superDrZhang, createdTime=Sun Jun 29 15:42:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9750, encodeId=577f9e509b, content=值得学习，很感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2d2103784, createdName=chen111111, createdTime=Mon Jun 09 15:51:00 CST 2014, time=2014-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507522, encodeId=d4d7150e522ca, content=<a href='/topic/show?id=28481685e91' target=_blank style='color:#2F92EE;'>#STUDY#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16857, encryptionId=28481685e91, topicName=STUDY)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1d9903165, createdName=yanghan, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624715, encodeId=a23f1624e1512, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9606, encodeId=24ef96066d, content=very good, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2014-10-17 jet747

    关键是获得数据后如何统计分析呢？

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=2027912, encodeId=e8fd202e912e7, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Sat Jul 05 04:04:00 CST 2014, time=2014-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12255, encodeId=084c1225598, content=关键是获得数据后如何统计分析呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRl88IIG7mnPw9aCyiclFjtObkW7hiaPluxVnP8W0L50Zk28TB6bOUvDAyD1p9jfvTD8fLIANPtx1tK/0, createdBy=0b0779675, 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIT1K5HVp6e14M3lDgTeribfs0NS0dVZvl53ibWm9N1TCxRBM0XgpicgHeORWZmrib5TEIZLr8mvy9Tvw/132, createdBy=1026104176, createdName=superDrZhang, createdTime=Sun Jun 29 15:42:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9750, encodeId=577f9e509b, content=值得学习，很感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2d2103784, createdName=chen111111, createdTime=Mon Jun 09 15:51:00 CST 2014, time=2014-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507522, encodeId=d4d7150e522ca, content=<a href='/topic/show?id=28481685e91' target=_blank style='color:#2F92EE;'>#STUDY#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16857, encryptionId=28481685e91, topicName=STUDY)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1d9903165, createdName=yanghan, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624715, encodeId=a23f1624e1512, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9606, encodeId=24ef96066d, content=very good, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2014-07-27 zgarycn

    新内容、新视野

    0

  6. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIT1K5HVp6e14M3lDgTeribfs0NS0dVZvl53ibWm9N1TCxRBM0XgpicgHeORWZmrib5TEIZLr8mvy9Tvw/132, createdBy=1026104176, createdName=superDrZhang, createdTime=Sun Jun 29 15:42:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9750, encodeId=577f9e509b, content=值得学习，很感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2d2103784, createdName=chen111111, createdTime=Mon Jun 09 15:51:00 CST 2014, time=2014-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507522, encodeId=d4d7150e522ca, content=<a href='/topic/show?id=28481685e91' target=_blank style='color:#2F92EE;'>#STUDY#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16857, encryptionId=28481685e91, topicName=STUDY)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1d9903165, createdName=yanghan, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624715, encodeId=a23f1624e1512, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9606, encodeId=24ef96066d, content=very good, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2014-06-29 superDrZhang

    太有用了！！值得学习

    0

  7. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIT1K5HVp6e14M3lDgTeribfs0NS0dVZvl53ibWm9N1TCxRBM0XgpicgHeORWZmrib5TEIZLr8mvy9Tvw/132, createdBy=1026104176, createdName=superDrZhang, createdTime=Sun Jun 29 15:42:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9750, encodeId=577f9e509b, content=值得学习，很感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2d2103784, createdName=chen111111, createdTime=Mon Jun 09 15:51:00 CST 2014, time=2014-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507522, encodeId=d4d7150e522ca, content=<a href='/topic/show?id=28481685e91' target=_blank style='color:#2F92EE;'>#STUDY#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16857, encryptionId=28481685e91, topicName=STUDY)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1d9903165, createdName=yanghan, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624715, encodeId=a23f1624e1512, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9606, encodeId=24ef96066d, content=very good, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2014-06-09 chen111111

    值得学习，很感兴趣

    0

  8. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIT1K5HVp6e14M3lDgTeribfs0NS0dVZvl53ibWm9N1TCxRBM0XgpicgHeORWZmrib5TEIZLr8mvy9Tvw/132, createdBy=1026104176, createdName=superDrZhang, createdTime=Sun Jun 29 15:42:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9750, encodeId=577f9e509b, content=值得学习，很感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2d2103784, createdName=chen111111, createdTime=Mon Jun 09 15:51:00 CST 2014, time=2014-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507522, encodeId=d4d7150e522ca, content=<a href='/topic/show?id=28481685e91' target=_blank style='color:#2F92EE;'>#STUDY#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16857, encryptionId=28481685e91, topicName=STUDY)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1d9903165, createdName=yanghan, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624715, encodeId=a23f1624e1512, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9606, encodeId=24ef96066d, content=very good, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2014-05-28 yanghan

    #STUDY#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=15002, encodeId=ff8215002de, content=以前没有听说过，很好！新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2a21613596, createdName=20142060, createdTime=Tue Feb 03 14:28:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647793, encodeId=16b2164e793d5, content=<a href='/topic/show?id=4e5e498336' target=_blank style='color:#2F92EE;'>#cohort#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4983, encryptionId=4e5e498336, topicName=cohort)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a9f23488497, createdName=guojianrong, createdTime=Sat Mar 07 19:04:00 CST 2015, time=2015-03-07, status=1, ipAttribution=), 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIT1K5HVp6e14M3lDgTeribfs0NS0dVZvl53ibWm9N1TCxRBM0XgpicgHeORWZmrib5TEIZLr8mvy9Tvw/132, createdBy=1026104176, createdName=superDrZhang, createdTime=Sun Jun 29 15:42:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9750, encodeId=577f9e509b, content=值得学习，很感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2d2103784, createdName=chen111111, createdTime=Mon Jun 09 15:51:00 CST 2014, time=2014-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507522, encodeId=d4d7150e522ca, content=<a href='/topic/show?id=28481685e91' target=_blank style='color:#2F92EE;'>#STUDY#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16857, encryptionId=28481685e91, topicName=STUDY)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1d9903165, createdName=yanghan, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624715, encodeId=a23f1624e1512, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Wed May 28 01:04:00 CST 2014, time=2014-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9606, encodeId=24ef96066d, content=very good, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2014-05-28 yaanren

    #Cas#

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c363103163, createdName=589690, createdTime=Tue May 27 20:45:00 CST 2014, time=2014-05-27, status=1, ipAttribution=)]
    2014-05-27 589690

    very good

    0

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