JCEM:头发皮质醇浓度与心脏代谢危险因素之间的相关性

2021-05-30 MedSci原创 MedSci原创

头发皮质醇浓度与6岁或10岁时心脏代谢危险因素无关,且独立于BMI。应激与心脏代谢危险因素之间的相关性可能在成年后有所进展。

应激与成人血管疾病相关。应激与心血管和代谢性疾病的关联可能源自儿童时期。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在探究6岁时头发皮质醇浓度与6岁和10岁时心脏代谢危险因素之间的相关性。

在荷兰鹿特丹的一项以人群为基础的前瞻性队列研究中,研究人员测量了6岁儿童(n=2598)头发中的皮质醇浓度。该研究的主要结局指标为6岁和10岁时的血压、心率、胰岛素、血糖、血脂和c反应蛋白浓度。

头发皮质醇浓度与血压和心率的关系

6岁时较高的头发皮质醇浓度与10岁时较高的收缩压相关(标准差评分(SDS)差异为0.17(95%可信区间(CI) 为0.03-0.31))。在对6岁儿童BMI进行校正后,这种相关性减弱,且不显著。6岁时较高的头发皮质醇浓度与6至10岁期间总胆固醇和低密度脂蛋白胆固醇增加相关,但与6至10岁时的测量结果无关。在6岁或10岁时的头发皮质醇浓度与其他心脏代谢危险因素没有显著的相关性。

由此可见,头发皮质醇浓度与6岁或10岁时心脏代谢危险因素无关,且独立于BMI。应激与心脏代谢危险因素之间的相关性可能在成年后有所进展

原始出处:

Florianne O L Vehmeijer.et al.Associations of hair cortisol concentrations with cardio-metabolic risk factors in childhood.JCEM.2021.https://doi.org/10.1210/clinem/dgab379

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    2022-05-04 achengzhao
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    2022-03-12 smallant2015
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    2021-05-31 qindq
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