Clin Gastroenterol H：社区幽门螺杆菌的筛查效果如何？

2017-06-18 xing.T MedSci原创

在这项长达13年随访的随机临床试验中，旨在证明HP人群筛查的效果，该研究结果表明在低发病率地区与常规治疗相比没有显著的长期效果。

根除幽门螺杆菌（HP）可以改善消化性溃疡疾病（PUD）、消化不良以及可能的胃癌预后。HP筛选试验较为准确，根除治疗较为有效。HP的人群筛查看起来很吸引人。近日，消化病领域权威杂志Clinical Gastroenterology and Hepatology发表了一篇研究文章，该研究的目的是评估人群HP筛查和根除HP对消化不良患病率和PUD发病率的长期影响，以及评估对医疗保健消费和生活质量的影响作为次要终点。

在基线1998年-1999年期间，共有20011名40岁-65岁的个人随机接受HP筛查和根除或没有筛查的对照处理。两组均接受关于消化不良和生活质量的问卷调查。研究人员获得了所有随机个体的注册数据。

基线问卷应答率为63%。在5749例接受筛查的患者中，1007例（17.5%）参与者为HP阳性。13年后，研究人员获得了8658（69%）名个人完整的症状数据。在随访期间两组消化不良患病率均有所下降，但多因素分析表明HP筛查和根除对其没有影响（比值比为0.93（0.82-1.04））；相比于常规治疗组。对登记数据进行意向治疗和按协议分析得到了类似的结果。HP筛查并不能显著降低PUD的发病率（调整后的比值比为0.88（0.70-1.11））也对医疗保健消费没有有利的影响。HP筛查对生活质量无长期效应。

在这项长达13年随访的随机临床试验中，旨在证明HP人群筛查的效果，该研究结果表明在低发病率地区与常规治疗相比没有显著的长期效果。

原始出处：

Maria Bomme Høgh,et al. Effects of Community Screening for Helicobacter pylori: 13-Year Follow-up of a Randomized Controlled Trial (HEP-FYN). Clinical gastroenterology and hepatology 2017. http://www.cghjournal.org/article/S1542-3565(17)30710-3/fulltext

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2018-02-28 许安

#GAS#

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2017-10-26 kcb069

#螺杆菌#

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2018-06-01 jktdtl

#Gastroenterol#

24 0
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objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 18:24:24 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212384, encodeId=0e612123842e, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jun 18 17:00:17 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212372, encodeId=58762123e272, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:20:43 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
2018-01-13 ms24272190615788285182

#AST#

26 0
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objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 18:24:24 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212384, encodeId=0e612123842e, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jun 18 17:00:17 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212372, encodeId=58762123e272, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:20:43 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
2017-06-21 大爰

学习并分享！！！

74 0
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objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 18:24:24 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212384, encodeId=0e612123842e, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jun 18 17:00:17 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212372, encodeId=58762123e272, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:20:43 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
2017-06-20 12498e67m28暂无昵称

#社区#

36 0
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encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Jan 13 08:10:00 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213381, encodeId=fbdb21338136, content=学习并分享！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jun 21 07:51:46 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395682, encodeId=44cd13956820d, content=<a href='/topic/show?id=7a89e4036eb' target=_blank style='color:#2F92EE;'>#社区#</a>, beContent=null, objectType=article, channel=null, level=null, 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objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 18:24:24 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212384, encodeId=0e612123842e, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jun 18 17:00:17 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212372, encodeId=58762123e272, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:20:43 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
2017-06-18 tanxingdoctor

学习啦！谢谢分享

54 0
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channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:20:43 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
2017-06-18 lovetcm

问卷的应答率偏低了仅有63%

43 0
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channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:20:43 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
2017-06-18 1e145228m78(暂无匿称)

学习了，谢谢作者分享!

53 0
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channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:20:43 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
2017-06-18 honghongwuwu

学习了，谢谢分享

60 0

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