Am J Resp Crit Care:2型糖尿病患者的阻塞性睡眠呼吸暂停与视网膜病变!

2017-06-10 xing.T MedSci原创

由此可见,OSA与T2D患者STDR相关。OSA是是前/增生性DR进展的独立预测因子,CPAP治疗与减少前期/增殖DR相关,需要干预性研究来评估OSA治疗对STDR的影响。

近日,呼吸内科以及重症医学领域权威杂志Am J Resp Crit Care上发表了一篇研究文章,研究人员旨在评估阻塞性睡眠呼吸暂停(OSA)与2型糖尿病患者糖尿病视网膜病变(DR)之间的相关性,并进一步评估OSA是否与其进展相关。

研究人员在英国两所医院的糖尿病门诊进行了纵向研究。已知有任何呼吸系统疾病(包括OSA)的患者被排除在外。每只眼睛采用2x45度视网膜图像来评估DR。研究人员采用家用多通道心肺装置来进行OSA评估。

该研究共纳入了230例患者。威胁视力的DR(STDR)和OSA的患病率分别为36.1%和63.9%。在OSA患者中STDR的患病率较高,相比于那些没有OSA的患者(42.9% vs. 24.1%(P=0.004)。调整混杂因素后,OSA仍然与STDR独立相关(比值比为2.3,95%可信区间为1.1-4.9,P=0.04)。经过中位(IQR)随访43个月(37.0-51.0),OSA患者更可能发展前/增生性DR,相比于无OSA的患者(18.4% vs. 6.1%,P=0.02)。调整混杂因素后,OSA仍是前/增生性DR进展的独立预测因子(比值比为5.2,95%可信区间为1.2-23.0,P=0.03)。接受持续气道正压通气(CPAP)治疗的患者发生前/增殖性DR的可能性较少。

由此可见,OSA与T2D患者STDR相关。OSA是是前/增生性DR进展的独立预测因子,CPAP治疗与减少前期/增殖DR相关,需要干预性研究来评估OSA治疗对STDR的影响。

原始出处:


Quratul A Altaf, et al. Obstructive Sleep Apnoea and Retinopathy in Patients with Type 2 Diabetes: A Longitudinal Study. AM J RESP CRIT CARE 2017.https://doi.org/10.1164/rccm.201701-0175OC.

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    2018-02-14 tomyang96
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    2017-06-12 zutt
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    2017-06-11 明天会更好!

    学习过了,很好值得分享!

    0

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    2017-06-11 tanxingdoctor

    学习啦谢谢分享

    0

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