我国学者主导国际共识在BMJ发表,轻型卒中应尽快给予氯吡格雷联合阿司匹林治疗

2019-03-04 刘志勇 健康报医生频道

3月1日,《英国医学杂志》刊登以首都医科大学附属北京天坛医院王拥军教授为第一作者和通讯作者,由中国、美国、英国、中国香港和台湾等多个国家和地区脑血管病抗血小板领域专家联合署名的《轻型卒中与短暂性脑缺血发作(TIA)患者抗血小板治疗国际专家共识》。 《共识》指出,对于24小时内的轻型卒中与TIA患者,应尽快给予氯吡格雷联合阿司匹林双联抗血小板治疗,并持续21天。


3月1日,《英国医学杂志》刊登以首都医科大学附属北京天坛医院王拥军教授为第一作者和通讯作者,由中国、美国、英国、中国香港和台湾等多个国家和地区脑血管病抗血小板领域专家联合署名的《轻型卒中与短暂性脑缺血发作(TIA)患者抗血小板治疗国际专家共识》。

共识》指出,对于24小时内的轻型卒中与TIA患者,应尽快给予氯吡格雷联合阿司匹林双联抗血小板治疗,并持续21天。

相关研究文章在系统回顾了轻型卒中和TIA患者氯吡格雷联合阿司匹林双联抗血小板的循证医学证据的基础上,从合适人群、时间窗与双抗治疗疗程等方面全面分析了轻型卒中和TIA患者双联抗血小板的证据,并达成共识。在如何更加精准地开展抗血小板治疗、是否可让更多患者从双抗治疗中获益及其在临床实践中的应用推广等方面,文章进一步指出未来轻型卒中和TIA患者抗血小板治疗的几个主要研究方向。

该国际共识的核心证据,来源于北京天坛医院国家神经系统疾病临床医学研究中心王拥军教授团队自主设计开展的大型临床试验——氯吡格雷治疗急性非致残性脑血管事件高危人群的疗效研究。该研究显示,联用氯吡格雷与阿司匹林(氯吡格雷起始剂量300毫克,随后75毫克/日直至90天,在前21天合并使用阿司匹林75毫克/日),与单用阿司匹林(阿司匹林75毫克/日,直至90天)比较,可显著降低轻型缺血性卒中和TIA患者90天时的卒中发生风险,且不增加出血风险。该研究于2013年结束后,相关研究结果陆续发表在多个国际权威学术期刊上,并被2013年国际卒中大会评为世界医疗十大最新研究进展之一。美国、中国、加拿大等国家的指南陆续进行了更新,推荐对轻型缺血性卒中和TIA患者采用氯吡格雷联合阿司匹林双联抗血小板治疗。

2018年年底,《英国医学杂志》召开脑血管病抗血小板治疗圆桌会议,该领域多名国际顶级专家参会并展开深入讨论,并最终达成此项国际专家共识。

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    2019-04-25 gaoxiaoe
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    2019-03-05 杨龙

    老编,原文题目怎么没引用一下?

    0

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    2019-03-05 topnew

    学习学习谢谢分享

    0

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    2019-03-05 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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2018年神刊《CA》发布了今年全球肿瘤的流行趋势,其数据显示肝癌已经成为发病率最高的肿瘤之一,而在我国肝癌患者的数目更是处于“基数大,逐年升”的状态,这其中原发性肝细胞癌人数又占了绝大多数。虽然近些年随着分子诊断技术的不断发展,肿瘤患者可以获得较为早期的诊断,但临床上可用的治疗方案却没有得到实质性的改善。因此,如何提高肝细胞肝癌患者的预后成为众多肿瘤研究者的“心头大患”。来自第二军医大丁劲教授,