Biol Psychiat CNNI:意外!婴儿期大脑发育或将预测儿童智商

2018-10-13 探索君 生物探索

美国2到8岁的儿童中,约有15%的儿童被诊断出至少有一种精神、行为或发育障碍。这些障碍包括学习困难、语言习得的延迟、注意力缺陷、自闭症和其他问题。近日,科学家们发现,婴儿时期大脑回路的生长速度可以帮助专家预测孩子在4岁时的智力和情感健康状况。

美国2到8岁的儿童中,约有15%的儿童诊断出至少有一种精神、行为或发育障碍。这些障碍包括学习困难、语言习得的延迟、注意力缺陷、自闭症和其他问题。近日,科学家们发现,婴儿时期大脑回路的生长速度可以帮助专家预测孩子在4岁时的智力和情感健康状况。

研究结果以“Development of Amygdala Functional Connectivity During Infancy and Its Relationship With 4-Year Behavioral Outcomes”为题发表在《Biological Psychiatry: Cognitive Neuroscience and Neuroimaging》杂志上。

在这项研究中,来自Cedars-Sinai医疗中心和北卡罗莱纳大学的研究小组评估了223名参与早期研究的儿童。研究人员对4岁的儿童进行了研究,以观察他们在婴儿时期的脑部扫描是否能预测他们日后的行为。除了专门为4岁儿童设计的用于衡量认知发展的智商测试外,研究人员还对孩子的父母进行了调查,并使用了标准化测试,如儿童行为评估系统和执行功能的行为评估量表,来衡量焦虑程度、自控能力和其他行为。

研究结果发现,尽管新生儿缺乏与成人大脑的连通性,但在出生后的第一年,大脑回路快速发育,随后在2岁时进行强化和微调。

Cedars-Sinai教授兼儿科系主任Charles Simmons医学博士说:“大量儿童面临着神经发育不良的风险,因此需要新的神经发育预测生物标志物。在不久的将来,我们或许能够更准确地诊断、干预和优化新生儿和婴儿的发育。”

通讯作者Wei Gao教授表示,研究小组的下一个目标是建立更全面的、基于图像的模型,以预测在幼儿时期和之后更广泛的发育结果。该团队还计划将其模型应用于高危人群,包括早产和产前药物暴露婴儿。

这项研究得到了Cedars-Sinai Precision Health公司的资助。

原始出处:Andrew P.Salzwedel, Rebecca L.Stephens, Barbara D.Goldman, et al. Development of Amygdala Functional Connectivity During Infancy and Its Relationship With 4-Year Behavioral Outcomes. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 30 August 2018

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    2019-03-12 sunylz
  4. 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createdBy=8ebc122, createdName=yankaienglish, createdTime=Mon Jun 17 17:57:00 CST 2019, time=2019-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918328, encodeId=ec64191832847, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Mar 12 14:57:00 CST 2019, time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323001, encodeId=d6481323001be, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347334, encodeId=1199134e3349e, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399539, encodeId=8e9213995399c, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614113, encodeId=3b4416141138b, content=<a href='/topic/show?id=a6824506923' target=_blank style='color:#2F92EE;'>#婴儿期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45069, encryptionId=a6824506923, topicName=婴儿期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e85919488444, createdName=108807375_62823133, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349261, encodeId=10c034926185, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sun Oct 14 09:38:45 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349188, encodeId=5800349188cc, content=有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Oct 13 17:48:49 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349183, encodeId=21163491832c, content=早发现早治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 13 17:31:37 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
    2018-10-15 晓辰
  5. [GetPortalCommentsPageByObjectIdResponse(id=1767527, encodeId=f9501e67527aa, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat Dec 08 03:57:00 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950540, encodeId=cc5a195054037, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Mon Jun 17 17:57:00 CST 2019, time=2019-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918328, encodeId=ec64191832847, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Mar 12 14:57:00 CST 2019, time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323001, encodeId=d6481323001be, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347334, encodeId=1199134e3349e, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399539, encodeId=8e9213995399c, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614113, encodeId=3b4416141138b, content=<a href='/topic/show?id=a6824506923' target=_blank style='color:#2F92EE;'>#婴儿期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45069, encryptionId=a6824506923, topicName=婴儿期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e85919488444, createdName=108807375_62823133, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349261, encodeId=10c034926185, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sun Oct 14 09:38:45 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349188, encodeId=5800349188cc, content=有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Oct 13 17:48:49 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349183, encodeId=21163491832c, content=早发现早治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 13 17:31:37 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
    2018-10-15 neurowu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1767527, encodeId=f9501e67527aa, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat Dec 08 03:57:00 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950540, encodeId=cc5a195054037, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Mon Jun 17 17:57:00 CST 2019, time=2019-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918328, encodeId=ec64191832847, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Mar 12 14:57:00 CST 2019, time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323001, encodeId=d6481323001be, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347334, encodeId=1199134e3349e, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399539, encodeId=8e9213995399c, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614113, encodeId=3b4416141138b, content=<a href='/topic/show?id=a6824506923' target=_blank style='color:#2F92EE;'>#婴儿期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45069, encryptionId=a6824506923, topicName=婴儿期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e85919488444, createdName=108807375_62823133, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349261, encodeId=10c034926185, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sun Oct 14 09:38:45 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349188, encodeId=5800349188cc, content=有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Oct 13 17:48:49 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349183, encodeId=21163491832c, content=早发现早治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 13 17:31:37 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1767527, encodeId=f9501e67527aa, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat Dec 08 03:57:00 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950540, encodeId=cc5a195054037, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Mon Jun 17 17:57:00 CST 2019, time=2019-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918328, encodeId=ec64191832847, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Mar 12 14:57:00 CST 2019, time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323001, encodeId=d6481323001be, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347334, encodeId=1199134e3349e, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399539, encodeId=8e9213995399c, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614113, encodeId=3b4416141138b, content=<a href='/topic/show?id=a6824506923' target=_blank style='color:#2F92EE;'>#婴儿期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45069, encryptionId=a6824506923, topicName=婴儿期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e85919488444, createdName=108807375_62823133, createdTime=Mon Oct 15 07:57:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349261, encodeId=10c034926185, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sun Oct 14 09:38:45 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349188, encodeId=5800349188cc, content=有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Oct 13 17:48:49 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349183, encodeId=21163491832c, content=早发现早治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 13 17:31:37 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
  8. 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GetPortalCommentsPageByObjectIdResponse(id=349183, encodeId=21163491832c, content=早发现早治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 13 17:31:37 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
    2018-10-14 kafei

    学习了谢谢

    0

  9. 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    2018-10-13 医者仁心5538

    有道理

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=349183, encodeId=21163491832c, content=早发现早治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Oct 13 17:31:37 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
    2018-10-13 flysky120

    早发现早治疗

    0

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