CMAJ：抑郁症增加老年患者住院风险
2012-12-21 CMAJ CMT 程蓓 编译
一项英国、澳大利亚、荷兰的联合研究显示，在老年人群中，与无抑郁症者相比，抑郁症患者因非精神疾病原因住院的风险更高，且住院时间更长、临床转归更差。论文12月10日在线发表于《加拿大医学会杂志》（CMAJ）。 研究纳入≥69岁的男性患者5411例。随访2年结果显示，在5072例无抑郁症者中有1164例（22.9%）至少1次急诊入院。与之相比，在339例抑郁症患者中有152例（44.8%）至少
一项英国、澳大利亚、荷兰的联合研究显示，在老年人群中，与无抑郁症者相比，抑郁症患者因非精神疾病原因住院的风险更高，且住院时间更长、临床转归更差。论文12月10日在线发表于《加拿大医学会杂志》（CMAJ）。
研究纳入≥69岁的男性患者5411例。随访2年结果显示，在5072例无抑郁症者中有1164例（22.9%）至少1次急诊入院。与之相比，在339例抑郁症患者中有152例（44.8%）至少1次急诊入院（P＜0.01）。多变量分析显示，罹患抑郁症是患者住院（风险比为1.67）、住院次数[发生率比（IRR）为1.22]、住院总时间（IRR为1.65）的显著独立相关因素。
与抑郁症相关的拓展阅读：
- 抑郁症增加老年患者住院风险
- Lancet：CBT 可缓解难治性抑郁症状
- Neurology：癫痫患者罹患抑郁症风险增加
- J AFFECT DISORDERS：常吃西红柿抑郁症减半
- NEUROPSYCHOPHARMACOL：研究发现抑郁症新型靶向疗法 更多信息请点击：有关抑郁症更多资讯
Background
Studies that have investigated the relation between depression and the type, nature, extent and outcome of general hospital admissions have been limited by their retrospective designs and focus on specific clinical populations. We explored this relation prospectively in a large, community-based sample of older men.
Methods
A cohort of 5411 men aged 69 years and older enrolled in the Health in Men Study was assessed at baseline for depressive symptoms, defined as a score of 7 or higher on the 15-item Geriatric Depression Scale. Participants were followed for 2 years for occurrence and number of hospital admissions, type of hospital admission, length of hospital stay and inpatient death as recorded in the Western Australian Data Linkage System.
Results
Of 339 men with depressive symptoms, 152 (44.8%) had at least 1 emergency hospital admission, compared with 1164 of 5072 (22.9%) nondepressed men (p < 0.001). In multivariate analyses, the presence of depressive symptoms was a significant independent predictor of hospital admission (hazard ratio 1.67, 95% confidence interval [CI] 1.38–2.01), number of hospital admissions (incidence rate ratio [IRR] 1.22, 95% CI 1.07– 1.39) and total length of hospital stay (IRR 1.65, 95% CI 1.36–2.01).
Interpretation
Participants with depressive symptoms were at higher risk of hospital admission for nonpsychiatric conditions and were more likely to have longer hospital stays and worse hospital outcomes, compared with nondepressed participants. These results highlight the potential to target this high-risk group to reduce the burden of health care costs in an aging population.
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本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
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#住院风险#
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