江泽飞教授:哪些乳腺癌临床实践可以被改变

2018-10-16 MedSci MedSci原创

江泽飞教授指出,随着乳腺癌精准治疗时代来临,应该在精准指导下对乳腺癌进行个体化的分类治疗。各个干预手段的“加减法”为乳腺癌治疗领域本年度最为热议的话题。减法由于后续治疗手段越来越充分,所以对于手术来说应该适当的做出“减法”。例如,更多的保乳术(BCT)代替了改良根治术(MRM),更多腋窝前哨淋巴结活检术(SLNB)代替了腋窝清扫术(ALND)。放射治疗方面,靶区体积也在逐渐的缩小,有些患者可以行部

江泽飞教授指出,随着乳腺癌精准治疗时代来临,应该在精准指导下对乳腺癌进行个体化的分类治疗。各个干预手段的“加减法”为乳腺癌治疗领域本年度最为热议的话题。减法由于后续治疗手段越来越充分,所以对于手术来说应该适当的做出“减法”。例如,更多的保乳术(BCT)代替了改良根治术(MRM),更多腋窝前哨淋巴结活检术(SLNB)代替了腋窝清扫术(ALND)。放射治疗方面,靶区体积也在逐渐的缩小,有些患者可以行部分乳房照射(APBI),甚至可以豁免。在精准时代中,辅助化疗方案也在一些患者中做出了“减法”,患者用药的周期数和个数都有做“减法”的尝试。 早期乳腺癌(EBC)的辅助化疗领域中,最早的标准为CMF×6方案;随着蒽环类的加入,研究证实AC×4方案与CMF×6方案效果类似,其周期数较少,所以AC方案逐渐成为了首选;紫杉类加入之后,研究证实AC×4→T×4要优于原有的AC方案,AC→T成为了标准治疗。随后,AC→T的方案正在进行剂量密集方案的优化与探索。加法乳腺癌治疗的“加法”主要来源于精准治疗。在内分泌治疗中,出现了CDK4/6抑制剂、mTOR抑制剂等与传统AI联合或互相联合的探索研究。

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    2018-12-12 jktdtl
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    2018-12-01 13718711b3m

    学习了,非常不错的临床经验,值得借鉴,获益匪浅,感谢分享!

    0

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    2018-10-17 随梦飞扬

    在内分泌治疗中,出现了CDK4/6抑制剂、mTOR抑制剂等与传统AI联合或互相联合的探索研究。

    0

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