AJOG:种族和产次对妊娠期糖尿病的影响(Meta分析)

2015-03-13 Mechront译 MedSci原创

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目前关于妊娠期糖尿病(GDM)复发率的研究众多,但是关于复发率的数值却众说纷纭,变化太大。近期Schwartz N等人进行了一项meta分析,以探究可能导致妊娠期糖尿病(GDM)复发率变化的原因以及亚组中的妊娠期糖尿病(GDM)的发生率合并值。

研究者们检索了Pubmed、Ovid、ClinicalTrials.gov和Google Scholar databases数据库,以及相关参考文献,时间限定为1973-2014.09,语言限定为英语,报道了GDM诊断标准和复发率的基于人群的研究。该文共纳入18篇相关文献,共计19,053名参与者。通过异质性检验值选择效应模型,计算合并后的GDM复发率;通过Meta回归分析研究间造成异质性的可能原因。 

研究结果显示,合并后妊娠期糖尿病(GDM)的复发率为48%(95% CI:41%-54%)。种族和GDM复发率明显相关(P=0.02),非西班牙籍白人(NHW)比其他种族有更低的GDM复发率(39% vs. 56%)。初产妇比经产妇有更低的GDM发生率(40% vs. 73,P<.0001)。没有数据表明妊娠期糖尿病(GDM)的复发与糖尿病家族史有关。 

该Meta分析结果表明,合并后妊娠期糖尿病(GDM)复发率很高;非西班牙籍白人(NHW)和初产妇会降低GDM发生率;GDM复发率与糖尿病家族史无关,所以种族间GDM发病率差异可能与遗传无关;因此可能存在减少GDM复发率的干预措施。 

原始出处:
Schwartz N, Nachum Z, Green MS.The prevalence of gestational diabetes mellitus recurrence - effect of ethnicity and parity: a meta-analysis. Am J Obstet Gynecol. 2015 Mar 7. pii: S0002-9378(15)00206-9. 

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    2015-08-09 guojianrong
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    2015-07-24 一闲
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