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CLIN CHEM：直接胆红素反流检测在早期胆道闭锁诊断中的应用

2018-03-27 MedSci MedSci原创

直接胆红素检测
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胆道闭锁的延迟诊断是小儿末期肝衰竭和肝移植失败的重要原因。近日国际杂志《CLIN CHEM》发表了一篇在线研究，研究人员试图通过回顾性检查胆道闭锁患者来确定直接胆红素是否未被充分利用。此外，研究目标还包括确定直接胆红素反射检测在疑似黄疸患者中的效用。 研究人员回顾性分析胆道闭锁患者总胆红素与直接胆红素测量的时间间隔。此外，还对审核了实施直接胆红素反射检测的两个主要实验室。并且评估了直接胆红素

胆道闭锁的延迟诊断是小儿末期肝衰竭和肝移植失败的重要原因。近日国际杂志《CLIN CHEM》发表了一篇在线研究，研究人员试图通过回顾性检查胆道闭锁患者来确定直接胆红素是否未被充分利用。此外，研究目标还包括确定直接胆红素反射检测在疑似黄疸患者中的效用。 研究人员回顾性分析胆道闭锁患者总胆红素与直接胆红素测量的时间间隔。此外，还对审核了实施直接胆红素反射检测的两个主要实验室。并且评估了直接胆红素增加（> 1.5 mg / dL;> 25μmol/ L）婴儿中的反射测试的临床效果和费用。 研究发现，在已知的胆道闭锁患者中，46％（40/87）的患者进行了直接胆红素测量后进行了单独的总胆红素测量; 中位延迟时间为19天（四分位间距为3-44天）。在社区中，直接胆红素对胆道闭锁的临床特异性高于医院。1591名年龄小于2周的婴儿在社区中报告直接胆红素结果的与三次入院相关，其中一名被诊断患有胆道闭锁。对于每个新诊断的胆道闭锁病例，两个直接胆红素检测实验室的费用估计为3200美元（4600新元）。 研究发现直接胆红素利用不足是导致识别胆道闭锁延迟诊断的原因，并表明对于黄疸婴儿直接胆红素的反

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    2018-03-28 zhangmingxiang

    #胆红素#

    0

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    2018-03-28 智者为医08

    #胆道闭锁#

    0

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    2018-03-28 feifers

    #反流#

    0

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    2018-03-28 海之蓝

    学习

    0

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    2018-03-27 明月清辉

    谢谢分享.学习了

    0

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