盘点：Diabetes Care 11月刊重要研究汇总

2017-11-02 MedSci MedSci原创

【1】无糖尿病人群的空腹血糖居然也影响心肌梗死DOI：10.2337/dc17-0610http://care.diabetesjournals.org/content/40/11/1565离散的FBG轨迹与无糖尿病个体随后发生MI的风险显着相关。近期，一项前瞻性队列研究评估了随时间变化的空腹血糖（FBG）水平变化及其对心肌梗死（MI）的潜在影响。研究共纳入了68297名没有糖尿病的患者。在2

【1】无糖尿病人群的空腹血糖居然也影响心肌梗死

 DOI：10.2337/dc17-0610

离散的FBG轨迹与无糖尿病个体随后发生MI的风险显着相关。近期，一项前瞻性队列研究评估了随时间变化的空腹血糖（FBG）水平变化及其对心肌梗死（MI）的潜在影响。研究共纳入了68297名没有糖尿病的患者。在2006年、2008年和2010年测量了受试者的FBG浓度。2006-2010年期间的FBG的变化曲线是此项研究的主要对象。结果表明，离散的FBG轨迹与无糖尿病个体随后发生MI的风险显着相关。FBG的长期轨迹对预测MI和其他大血管疾病的风险可能发挥重要作用。

【2】心肺适应对肥胖儿童心脏代谢和胰岛素抵抗的影响

DOI：10.2337/dc17-1334

近期，一项新的研究合并了三个横断面研究项目，调查了：1）不同BMI分类（由低体重至病态肥胖）的心脏代谢风险和胰岛素抵抗的HOMA（HOMA-IR）的差异；2）在不同BMI分类中，适应儿童的心脏代谢风险/ HOMA-IR是否低于不适应的儿童风险；3）正常体重的不适应儿童和肥胖适应儿童的心脏代谢风险/ HOMA-IR之间的差异。结果表明，随着BMI类别的升高，心脏代谢风险和HOMA-IR也强调了儿童期肥胖预防/治疗计划的需要。此外，CRF可能在降低肥胖儿童心脏代谢疾病的风险中起重要作用。

【3】长效或短效磺脲类药物治疗的心血管风险无差异

DOI：10.2337/dc17-0595

近期，英国的一项研究对1998-2013年英国临床实践研究数据库中成年2型糖尿病患者（平均年龄，68岁）数据进行了分析。结果显示，胰腺特异性、短效磺脲类药物和胰腺非特异性、长效磺脲类药物的主要不良心血管事件风险、心血管死亡和全因死亡风险无显著差异。但是，与短效药物相比，接受长效磺脲类药物治疗的患者严重低血糖风险更高。

【4】外分泌胰腺糖尿病的临床特征

DOI：10.2337/dc17-0542

近期，来自英国的一项研究描述了胰腺疾病后糖尿病的发病率，评估了这些患者如何被临床医生分类，并比较了1型和2型糖尿病的临床特征。共纳入了31789例成人新发病糖尿病。结果显示，与2型糖尿病相比，胰腺疾病后的糖尿病与血糖控制不佳。5年内2型糖尿病患者胰岛素使用量为4.1％，急性胰腺炎后糖尿病者为20.9％，慢性胰腺疾病后糖尿病者为45.8％。表明外分泌胰腺的糖尿病经常被认为2型糖尿病，但是其血糖控制较差，对胰岛素的需求显着增加。

【5】SGLT2抑制剂服用者发生急性肾损伤的风险分析

DOI：10.2337/dc17-1011

钠-葡萄糖转运体2（SGLT2）抑制剂是一种新药物，可以改善2型糖尿病患者的心血管疾病和肾脏结局。然而，美国食品和药物管理局对于canagliflozin和dapagliflozin增加急性肾损伤（AKI）的风险已发出警报。近日，新的一项研究旨在通过两个大型卫生服务使用T2D患者队列来评估服用SGLT2抑制剂发生的AKI风险。研究人员使用了西奈山慢性肾脏病注册中心和Geisinger健康系统队列的纵向数据进行分析。研究人员选择了SGLT抑制剂使用者和非使用者（没有服用SGLT2抑制剂的患者）。结果并未表明AKI风险增加与T2D患者服用SGLT2抑制剂有关。

【6】识别青少年1型糖尿病的现状

DOI：10.2337/dc17-0441

来自澳大利亚的一项研究建立了青少年糖尿病（PAID-T）规模的分界线，以确定具有临床意义和糖尿病高危险的青少年。受试者完成了糖尿病困扰（PAID-T）和抑郁症状（青少年患者健康问卷）的测量，并自行报告了他们最近的HbA1c水平和血糖自我监测的频率（SMBG）。研究者们检查了PAID-T与心理和临床变量之间的关系，以确定糖尿病高危患者临床意义上的阈值。使用ANOVA评估上述变量是否随高危水平而不同。结果表明，使用PAID-T确定了两个临床意义上的切入点，以区分青少年（13-19岁）的无至轻度，中度和重度糖尿病。基于这些切入点，大多数受访者经历了至少中度的糖尿病困扰，这在临床上具有重要的意义。

【7】肝细胞核因子1B分子缺陷与糖尿病有关

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2018-07-20 ms9608593228839890

#DIA#

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2018-04-03 木头人513

#Diabetes#

19 0
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2018-07-31 ms5439512287675881

#BET#

14 0
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2017-11-03 李东泽

是很好的学习材料.不错.以后会多学习.

31 0
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2017-11-03 大叔默默路过

不错的分享

46 0
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2017-11-03 明月清辉

谢谢分享.学习了

39 0
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Nov 03 07:09:54 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258218, encodeId=48b425821807, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Fri Nov 03 05:01:54 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258191, encodeId=3ab8258191e1, content=离散的FBG轨迹与无糖尿病个体随后发生MI的风险显着相关., beContent=null, objectType=article, 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2017-11-03 yjs木玉

好好好好好好好好

30 0
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2017-11-02 有备才能无患

离散的FBG轨迹与无糖尿病个体随后发生MI的风险显着相关.

36 0
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2017-11-02 happsf

学习

15 0
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channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Nov 02 23:49:55 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258182, encodeId=2c4b258182d4, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Thu Nov 02 23:24:49 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258179, encodeId=8c602581e95a, content=不错啊文章值得一读.不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=11, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Nov 02 23:02:00 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
2017-11-02 1e1b8538m79(暂无匿称)

不错啊文章值得一读.不错啊

11 0