Toxicol Sci:一些双酚A类似物的使用风险并不比双酚A低!

2017-09-13 Emma MedSci原创

BPA,即双酚A,是由苯酚、丙酮在酸性介质中合成的,是环氧树脂、聚碳酸酯、聚砜、聚芳酯、酚醛树脂、不饱和聚酯树脂、阻燃剂等产品的重要原料。

BPA,即双酚A,是由苯酚、丙酮在酸性介质中合成的,是环氧树脂、聚碳酸酯、聚砜、聚芳酯、酚醛树脂、不饱和聚酯树脂、阻燃剂等产品的重要原料。因其具有雌激素活性,对人体具有潜在的不良健康影响,引起其在消费类产品,和食品容器使用方面的担忧。美国食品和药物管理局(FDA)2010年的报告,提出了BPA对 胎儿,婴儿和儿童可能有害,但报告确认了某些食品中出现的极低浓度是安全的。 2010年9月,加拿大成为第一个国家宣布BPA有毒的物质。欧盟,加拿大,以及美国已经禁止婴儿奶瓶中的BPA使用。由于这些健康影响的证据越来越多,BPA正在逐步淘汰,由"无BPA"产品中的其他双酚变体代替。

研究人员在三种人类乳腺癌细胞系中比较了BPA与6种双酚类似物(双酚S,BPS;双酚F,BPF;双酚AP,BPAP;双酚AF,BPAF;双酚Z,BPZ;双酚B,BPB)的雌激素活性。结果显示,BPA替代物在人乳腺癌细胞中表现出的类雌激素作用并不比BPA少,并且BPAF,BPB和BPZ比BPA的类雌激素作用更强。该研究结果提示,对于双酚A替代品的使用风险(如对激素依赖性乳腺癌的影响)的了解仍需进一步深入。

通过在雌激素受体(ER)介导的细胞增殖测定中细胞的生长情况和在荧光素酶测定中诱导雌激素反应元件介导的转录评估雌激素水平(10-11M to 10-4M)。

结果显示,BPAF是雌激素活性最有效的双酚,其次是BPB> BPZBPA> BPFBPAP> BPS。ICI 182,780的添加拮抗了ERs的激活。ToxCast高通量筛选测定数据分析证实了该结果,而且还表现出分析灵敏度的差异。研究人员通过基因芯片确定了MCF-7细胞的基因表达谱,由BPA替代物与ERα基因表达生物标志物产生的转录组谱变化的比较进一步表明, BPA替代物在MCF-7细胞中都具有作为ERα激动剂的作用,基于Illumina的RNA测序也显示了相同的结果。

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    2017-09-18 1e10c84am36(暂无匿称)

    文章真好.值得分享

    0

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    2017-09-17 luominglian113

    学习了.谢谢分享

    0

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    2017-09-15 䖝二

    学习了

    0

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    2017-09-15 zhaojie88
  5. [GetPortalCommentsPageByObjectIdResponse(id=245201, encodeId=e06024520141, content=文章真好.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Sep 18 06:44:42 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244807, encodeId=572524480ee6, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 17 00:00:19 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244427, encodeId=e03824442e3d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Fri Sep 15 23:44:22 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350107, encodeId=e20c135010ee6, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Sep 15 09:40:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244228, encodeId=90ef24422888, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Fri Sep 15 08:15:30 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243850, encodeId=b0dd2438509e, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Sep 14 09:12:12 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243692, encodeId=a76024369244, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Sep 13 23:39:44 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243611, encodeId=371f24361120, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Sep 13 19:09:53 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243605, encodeId=75ab243605b4, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Sep 13 19:08:04 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-15 lietome15

    好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=245201, encodeId=e06024520141, content=文章真好.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Sep 18 06:44:42 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244807, encodeId=572524480ee6, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 17 00:00:19 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244427, encodeId=e03824442e3d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Fri Sep 15 23:44:22 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350107, encodeId=e20c135010ee6, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Sep 15 09:40:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244228, encodeId=90ef24422888, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Fri Sep 15 08:15:30 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243850, encodeId=b0dd2438509e, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Sep 14 09:12:12 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243692, encodeId=a76024369244, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Sep 13 23:39:44 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243611, encodeId=371f24361120, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Sep 13 19:09:53 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243605, encodeId=75ab243605b4, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Sep 13 19:08:04 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-14 139****5926

    好好文章学习了

    0

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    2017-09-13 130****4638

    学习了受益匪浅

    0

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    2017-09-13 flysky120

    学习一下知识了

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    2017-09-13 131****1460

    学习了受益匪浅

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