糖尿病

订阅

MedSci主页 / 所有栏目 / 糖尿病

一年只需给药一次的降糖药，或于2016年递交上市申请

2015-11-07 MedSci MedSci原创

降糖药物
关注

Intarcia Therapeutics的CEO Kurt Graves Ⅱ型糖尿病是一种使人逐渐衰弱和致命的疾病，目前全球有近3亿5千万患者。并且患者需要每天监测血糖，服用药物，十分痛苦。来自美国的Intarcia Therapeutics公司决心改变这种状况。 Intarcia Therapeutics成立于1997年，这是一家生物医药公司，也是医疗行业最早进入独角兽俱乐


Intarcia Therapeutics的CEO Kurt Graves

Ⅱ型糖尿病是一种使人逐渐衰弱和致命的疾病，目前全球有近3亿5千万患者。并且患者需要每天监测血糖，服用药物，十分痛苦。来自美国的Intarcia Therapeutics公司决心改变这种状况。

Intarcia Therapeutics成立于1997年，这是一家生物医药公司，也是医疗行业最早进入独角兽俱乐部的公司，2014年4月正式跨入“独角兽俱乐部”，估值达到了55亿美元。目前，这家位于美国波士顿的公司已经在10轮融资中累计获得了超过7.59亿美元投资。

该公司主要致力于研发结合科技与药物的创新性疗法，并主要专注于流行病和极难控制的疾病。自2012年以来，该公司一直从事于一年使用一次的糖尿病疗法的开发。

一直以来，糖尿病等重大慢性疾病的研发都充斥着各个医药巨头的身影，许多分析人士都认为小型生物医药公司很难有足够的创造力、财力和执行力来完成这些重大疾病药物的研发。显然Intarcia公司希望挑战这一铁律。

目前糖尿病市场中，GLP-1药物正方兴未艾，其中尤以糖尿病药物巨头诺和诺德开发的GLP-1药物Victoza最为著名，但是这种药物需要每周甚至每天进行注射以保持患者血糖稳定在一定浓度。


而Intarcia Therapeutics开发的糖尿病药物ITCA650则是一种植入皮下的微型真空泵，这款火柴棒大小的渗透泵将提供持续的 GLP-1 激动剂艾塞那肽，进而达到降低糖尿病患者血糖水平的目的，并且该药物最大特点是一年只需给药一次。

Intarcia Therapeutics还表示，有资格的医师、护士或医师助理可以在医生办公室通过一个简单的 5 分钟操作就可以放置 ITCA 650，如果获得批准，ITCA 650 将成为首款也是仅有的无需注射的 GLP-1 治疗药物，它可通过一次剂量输送一整年的治疗药物。

在公司进行的第一项临床三期研究中，研究人员招募了约460名糖化血红蛋白水平在7.5%-10%之间的二型糖尿病患者，经过约39周的治疗后，数据显示相对于安慰剂组，接受ITCA650治疗的患者血糖被稳定控制在7%以下，达到了研究之初的首要终点设计。在另一项关于治疗血糖浓度在10%以上的患者的临床三期研究中，数据显示经过9个月的治疗，有25%的患者血糖浓度降低至7%以下。而这一结果也被认为是Intarcia公司取得的一项重大突破。

在今年4月获得了一笔高达2.25亿美元的投资之后，Intarcia Therapeutics的CEO Kurt Graves也表示公司暂时并不打算寻找共同开发ITCA 650的合作伙伴。他同时也表示，预计将于今年完成与默沙东公司糖尿病药物Januvia的对比研究，并最早将于2016年向有关部门提交上市申请。

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (14)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-09 minlingfeng

    #降糖药#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-09 fuwen

    赞

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-09 1ddb1158m49(暂无匿称)

    慢性高血压是不是也可以来这个

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-09 linglong1990

    赞

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-08 liusanxin

    我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-08 wwju127

    科技日新月异啊

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-08 240612799

    真厉害

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-08 medcardio

    技术牛X呀

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-08 1dde1feem74(暂无匿称)

    真心赞

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1270821, encodeId=8d4012e08219c, content=<a href='/topic/show?id=4066981e99e' target=_blank style='color:#2F92EE;'>#降糖药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98179, encryptionId=4066981e99e, topicName=降糖药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Nov 09 14:40:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42881, encodeId=c116428815a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62dd1636068, createdName=fuwen, createdTime=Mon Nov 09 11:42:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42874, encodeId=6dfe428e43a, content=慢性高血压是不是也可以来这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ab1b1644256, createdName=1ddb1158m49(暂无匿称), createdTime=Mon Nov 09 08:03:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42869, encodeId=0692428697d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05151605011, createdName=linglong1990, createdTime=Mon Nov 09 00:16:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42852, encodeId=5bff42852e8, content=我感觉如果可以的话，其他的疾病也可以用这个东西来搞啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Sun Nov 08 16:18:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42851, encodeId=76d24285146, content=科技日新月异啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9bc83178, createdName=wwju127, createdTime=Sun Nov 08 15:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42850, encodeId=bb4c42850de, content=真厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Sun Nov 08 15:03:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42842, encodeId=8d6042842b1, content=技术牛X呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:38:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42829, encodeId=5dc442829f8, content=真心赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=508d1658191, createdName=1dde1feem74(暂无匿称), createdTime=Sun Nov 08 11:42:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42824, encodeId=f24d42824ec, content=啧啧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:28:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-08 IIIi

    啧啧

    0

以上为热门评论，梅斯医学App还有更多内容

相关资讯

Nature：揭示二甲双胍降糖新机制

　　《自然》（Nature）杂志近期发表的一项研究揭示了二甲双胍潜在的降糖新机制。此前的理论认为二甲双胍通过激活AMPK从而减少肝脏葡萄糖合成，而新的研究表明，二甲双胍通过诱导AMP和抑制腺苷酸环化酶的核苷酸在肝细胞内聚集，降低cAMP和PKA活性，PKA关键蛋白磷酸化步骤被阻止，因而肝细胞胰高血糖素依赖的葡萄糖输出被抑制。 　　研究由宾夕法尼亚大学Perelman医学院糖尿病、肥胖和代谢

降糖减肥双获益，糖尿病鸡尾酒欧盟上市

糖尿病巨头诺和诺德（Novo Nordisk）近日宣布，将瑞士定为商业化推出糖尿病鸡尾酒Xultophy（IDegLira）的首个欧盟国家，该药同时将在2015年间陆续在其他欧盟成员国上市。Xultophy是全球首个长效胰岛素和GLP-1受体激动剂复方药，兼具降糖和减肥功效，对广大2型糖尿病群体而言，是一大福音！业界预测，Xultophy将成为诺和诺德又一枚重磅产品，年销售峰值将突破10亿美元

Lancet Diab & Endo：依帕列净二线降糖不劣于格列美脲

近期发表的一项为期104周的随机、活性药物对照、双盲、Ⅲ期临床研究表明，在2型糖尿病患者中，当二甲双胍治疗失败时，加用SGLT2抑制剂依帕列净对HbA1c的降低效果不劣于加用格列美脲。两种联用策略的不良反应和严重不良反应发生率均无显著差异，依帕列净组的低血糖事件发生率明显低于格列美脲组（2% vs 24%）。 原始出处： Ridderstråle M

AAOS 2014：降糖药对长管状骨骨折术后愈合有影响

人们早就知道糖尿病会影响骨组织损伤后的修复，可在不同阶段导致骨折愈合的延迟。但是，近来多数糖尿病患者通过使用药物来使其机体的高血糖内环境恢复正常。到目前为止，尚无研究探讨过降糖药物对人类骨折愈合的影响。与此相应的是，仅在英国一个国家，每年就有超过40000名糖尿病患者因为创伤和骨科损伤而接受手术治疗，预计到2025年时这类患者的数量会超过52000名。本研究旨在通过与非糖尿

ADA 2014：降糖：脂肪肝新疗法？

ADA大会上中国专场研究巡礼将为您呈现第4项入选研究、南京大学医学院附属鼓楼医院教授领导的“艾塞那肽、胰岛素、吡格列酮对新诊断2型糖尿病患者肝脏脂肪含量及体脂分布的影响”研究。[报告时间：6月13日15:20~15:40，地点：S-302(South Building)]。 研究背景：降糖可以减少肝脏脂肪含量?       

AJG：降糖药与胰腺癌发病风险的关系尚不明确

图1. Meta分析流程图 胰腺癌是常见的恶性肿瘤。胰腺癌恶性程度高，预后差，5年存活率约5%左右。因胰腺癌诊断时大多已处于晚期，即使可以采用手术方法切除癌肿，但5年存活率仍只有10-20%。引起胰腺癌的原因至今尚不十分清楚，但已明确存在多种危险因素，包括吸烟、饮酒、慢性胰腺炎、肥胖以及具有胰腺癌家族史等，都可增加胰腺癌的患病风险。因目前仍缺乏影响胰腺癌预后及成本效益的相关研究，所以鉴定胰腺癌患