JASN：高酸饮食增加终末期肾病风险

2015-03-02 佚名生物谷

最新一期的JASN刊登的一篇研究表示如果患有慢性肾病的患者饮食具有高酸含量，可能会增加肾衰竭的风险。慢性肾病患者可能要限制肉类的摄入量，增加水果和蔬菜，以帮助保护他们的肾脏。之前有小规模的临床试验结果表明，降低膳食酸负荷(dietary acid load ，DAL)能改善肾损伤，延缓肾功能衰退。可是DAL和患有慢性肾病(CKD)患者发展终末期肾病(ERSD)风险之间的关系却不

最新一期的JASN刊登的一篇研究表示如果患有慢性肾病的患者饮食具有高酸含量，可能会增加肾衰竭的风险。慢性肾病患者可能要限制肉类的摄入量，增加水果和蔬菜，以帮助保护他们的肾脏。

之前有小规模的临床试验结果表明，降低膳食酸负荷(dietary acid load ，DAL)能改善肾损伤，延缓肾功能衰退。可是DAL和患有慢性肾病(CKD)患者发展终末期肾病(ERSD)风险之间的关系却不甚明了。加州大学旧金山分校的Tanushree博士和她的同事们为了研究这个问题，收集了全美1486位代表性的患有CKD成年人的样本，通过量化净酸排泄(NAEes)的方法检测DAL同时追踪患者肾病的发展。14.2年随访后，通过ERSD医保注册确认是否有晚期肾病。

研究人员采用FINE-GRAY竞争风险的方法来评估DAL与ERSD的关联(在考虑了人口统计，营养因素，临床疾病，肾功能/损伤标记物等因素后)。结果发现311(20.9%)位参与者发展有ERSD，高 DAL水平增加ESRD的相关风险——相对危险(95%置信区间)为3.04(1.58~5.86)为高，1.81(0.89~3.68)为中等水平。参与者如果有蛋白尿，高DAL显示与ESRD的风险强烈相关。所以较高水平的膳食酸负荷与发展肾功能衰竭强烈联系在一起。消耗高酸的饮食患者比消耗低酸性饮食的病人发展肾功能衰竭可能高出三倍。

低酸负荷饮食包括丰富的水果和蔬菜，而高酸的饮食中含有较多的肉类。患有慢性肾脏疾病可能要多注意饮食中酸丰富的食物，以减少发展为肾功能衰竭可能，同时听从医生建议，服用药物，避免肾毒素。Tanushree博士表示：透析治疗带来高费用和欠佳生活质量可采用更健康的含有丰富的水果和蔬菜的饮食来避免。

原始出处：

Banerjee T1, Crews DC2, Wesson DE3, Tilea AM4, Saran R5, Ríos-Burrows N6, Williams DE6, Powe NR7; for the Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team.High Dietary Acid Load Predicts ESRD among Adults with CKD.J Am Soc Nephrol. 2015 Feb 12. pii: ASN.2014040332. [Epub ahead of print]

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2015-03-13 anminleiryan

#终末期#

32 0
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2015-03-04 chenhongpeng

#ASN#

33 0
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2015-07-29 sundong

那就吃优质蛋白吧

128 0
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authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Mon Mar 02 18:05:00 CST 2015, time=2015-03-02, status=1, ipAttribution=)]
2015-04-11 x35042875

轻度肾脏疾病对母亲和婴儿可能会增加孕期风险

103 0
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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:03:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476341, encodeId=a5b714e634125, content=<a href='/topic/show?id=eb69e81665d' target=_blank style='color:#2F92EE;'>#终末期肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78166, encryptionId=eb69e81665d, topicName=终末期肾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb27278676, createdName=zengjiayao, createdTime=Wed Mar 04 00:32:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17379, encodeId=11431e37905, content=如何注册？, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Mon Mar 02 18:05:00 CST 2015, time=2015-03-02, status=1, ipAttribution=)]
2015-04-11 x35042875

轻度肾脏疾病对母亲和婴儿可能会增加孕期风险

107 0
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authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Mon Mar 02 18:05:00 CST 2015, time=2015-03-02, status=1, ipAttribution=)]
2015-03-31 x35042875

松治疗有效没？好文章

130 0
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2015-03-31 x35042875

为肾功能衰竭可能，同时听从医生建议，服用药物，避免肾毒素。Tanushree博士表示：透析治疗带来高费用和欠佳生活质

65 0
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createdName=chenhongpeng, createdTime=Wed Mar 04 00:32:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33742, encodeId=3f7933e4253, content=那就吃优质蛋白吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Wed Jul 29 11:00:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20238, encodeId=b36920238c1, content=轻度肾脏疾病对母亲和婴儿可能会增加孕期风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:26:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19199, encodeId=8109191992e, content=为肾功能衰竭可能，同时听从医生建议，服用药物，避免肾毒素。Tanushree博士表示：透析治疗带来高费用和欠佳生活质, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:24:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17624, encodeId=8a4e1e62416, content=好文章，攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:03:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476341, encodeId=a5b714e634125, content=<a href='/topic/show?id=eb69e81665d' target=_blank style='color:#2F92EE;'>#终末期肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78166, encryptionId=eb69e81665d, topicName=终末期肾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb27278676, createdName=zengjiayao, createdTime=Wed Mar 04 00:32:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17379, encodeId=11431e37905, content=如何注册？, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Mon Mar 02 18:05:00 CST 2015, time=2015-03-02, status=1, ipAttribution=)]
2015-03-05 xiaoai5777

好文章，攒

48 0
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createdName=chenhongpeng, createdTime=Wed Mar 04 00:32:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33742, encodeId=3f7933e4253, content=那就吃优质蛋白吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Wed Jul 29 11:00:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20238, encodeId=b36920238c1, content=轻度肾脏疾病对母亲和婴儿可能会增加孕期风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:03:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476341, encodeId=a5b714e634125, content=<a href='/topic/show?id=eb69e81665d' target=_blank style='color:#2F92EE;'>#终末期肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78166, encryptionId=eb69e81665d, topicName=终末期肾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb27278676, createdName=zengjiayao, createdTime=Wed Mar 04 00:32:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17379, encodeId=11431e37905, content=如何注册？, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Mon Mar 02 18:05:00 CST 2015, time=2015-03-02, status=1, ipAttribution=)]
2015-03-04 zengjiayao

#终末期肾病#

34 0
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createdName=chenhongpeng, createdTime=Wed Mar 04 00:32:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33742, encodeId=3f7933e4253, content=那就吃优质蛋白吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Wed Jul 29 11:00:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20238, encodeId=b36920238c1, content=轻度肾脏疾病对母亲和婴儿可能会增加孕期风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:26:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19199, encodeId=8109191992e, content=为肾功能衰竭可能，同时听从医生建议，服用药物，避免肾毒素。Tanushree博士表示：透析治疗带来高费用和欠佳生活质, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:24:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17624, encodeId=8a4e1e62416, content=好文章，攒, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Thu Mar 05 11:03:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476341, encodeId=a5b714e634125, content=<a href='/topic/show?id=eb69e81665d' target=_blank style='color:#2F92EE;'>#终末期肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78166, encryptionId=eb69e81665d, topicName=终末期肾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb27278676, createdName=zengjiayao, createdTime=Wed Mar 04 00:32:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17379, encodeId=11431e37905, content=如何注册？, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Mon Mar 02 18:05:00 CST 2015, time=2015-03-02, status=1, ipAttribution=)]
2015-03-02 MedSci客户端网友

如何注册？

83 0

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