Ann Oncol：江泽飞等发现循环肿瘤细胞为中国乳腺癌患者生存独立预测因素

2013-07-18 ecoliDH5 dxy

在2013年7月14日在线出版的《肿瘤学年鉴》(Annals of Oncology)杂志上，发表了中国军事医学科学院江泽飞教授等人的一项研究成果，该项多中心、双盲、前瞻性研究针对中国转移性乳腺癌(MBC)女性患者，旨在评价循环肿瘤细胞(CTC)测定在预测抗癌治疗手段缓解率方面的潜在应用价值，其中包括人表皮生长因子受体-2(HER-2)靶向药物相关缓解情况、无进展生存期(PFS)以及总生存期(OS

在2013年7月14日在线出版的《肿瘤学年鉴》(Annals of Oncology)杂志上，发表了中国军事医学科学院江泽飞教授等人的一项研究成果，该项多中心、双盲、前瞻性研究针对中国转移性乳腺癌(MBC)女性患者，旨在评价循环肿瘤细胞(CTC)测定在预测抗癌治疗手段缓解率方面的潜在应用价值，其中包括人表皮生长因子受体-2(HER-2)靶向药物相关缓解情况、无进展生存期(PFS)以及总生存期(OS)。

在研究中，共有300例MBC患者计划完成3次CTC血样采集，并参与两项影像学研究。在6家中国前沿癌症中心所招募的300例MBC患者中，共有294例为可评价性患者。多变量Cox回归分析表明，基线CTC数目仍然为PFS ([风险比 (HR) = 1.93; 95% 置信区间(CI) = 1.39–2.69; P < 0.001)及OS (HR = 3.76; 95% CI = 2.35–6.01; P < 0.001)的独立预后因素。首次随访结果发现，也可得到PFS(P = 0.049)及OS (P < 0.001)的类似结果。

江教授等人认为，CTC计数可为中国MBC患者提供较为确切的预后信息，并可作为PFS与OS相关的独立因素。此外，该研究表明，对于包括HER-2阳性病情在内的各亚型疾病，无论治疗手段如何，CTC计数均具有预后价值。

Circulating tumor cells predict progression-free and overall survival in Chinese patients with metastatic breast cancer

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2015-10-18 hlycom3356

这篇文章写得很好

143 0
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2015-10-18 hlycom3356

这篇文章写得很好

139 0
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2015-10-18 hlycom3356

这篇文章写得很好

185 0
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2015-10-18 hlycom3356

这篇文章写得很好

137 0
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2015-02-28 xiaoai5777

不错的文章，学习了

139 0
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2014-02-17 jktdtl

#江泽飞#

39 0
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2014-06-25 minlingfeng

#Oncol#

38 0
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2014-02-11 tastas

#患者生存#

37 0
[GetPortalCommentsPageByObjectIdResponse(id=39224, encodeId=788b39224d7, content=这篇文章写得很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 18 21:40:00 CST 2015, time=2015-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=39225, encodeId=bd613922523, content=这篇文章写得很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 18 21:40:00 CST 2015, time=2015-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=39226, encodeId=32a439226b9, content=这篇文章写得很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 18 21:40:00 CST 2015, time=2015-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=39227, encodeId=6ca13922e0e, content=这篇文章写得很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 18 21:40:00 CST 2015, time=2015-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17224, encodeId=ed781e224fb, content=不错的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sat Feb 28 11:05:00 CST 2015, time=2015-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755835, encodeId=860d1e558350e, content=<a href='/topic/show?id=57a564331cd' target=_blank style='color:#2F92EE;'>#江泽飞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64331, encryptionId=57a564331cd, topicName=江泽飞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3c337051995, createdName=jktdtl, createdTime=Mon Feb 17 06:06:00 CST 2014, time=2014-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864470, encodeId=26f118644e03c, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed Jun 25 17:06:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932480, encodeId=c3331932480a2, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53058, encryptionId=5cd95305803, topicName=患者生存)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Tue Feb 11 15:06:00 CST 2014, time=2014-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264189, encodeId=3c501264189f1, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Sat Jul 20 04:06:00 CST 2013, time=2013-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312881, encodeId=91ca13128813f, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sat Jul 20 04:06:00 CST 2013, time=2013-07-20, status=1, ipAttribution=)]
2013-07-20 朱睿睿

#预测因素#

28 0
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2013-07-20 hmwwww

#肿瘤细胞#

27 0

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Ann Oncol：江泽飞等发现循环肿瘤细胞为中国乳腺癌患者生存独立预测因素

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