Cell Rep:低剂量锂或可延长人类寿命

2016-04-10 MedSci MedSci原创

资料图:金属锂。 中新网4月8日电 据英国媒体报道,英国科学家近期发表在《细胞报告》(Cell Reports)杂志上的报告显示,低剂量的锂(lithium)可以延长果蝇的寿命。 据报道,在实验室状态下的研究结果表明,摄入低剂量锂的果蝇比一般果蝇的寿命长16%,但使用大剂量的锂将会缩短果蝇的寿命。 科学家说,这项研究结果令人鼓舞,也许能够最终导致延长人类寿命或保持生命健康的新药问世。

资料图:金属锂。资料图:金属锂。

中新网4月8日电 据英国媒体报道,英国科学家近期发表在《细胞报告》(Cell Reports)杂志上的报告显示,低剂量的锂(lithium)可以延长果蝇的寿命。

据报道,在实验室状态下的研究结果表明,摄入低剂量锂的果蝇比一般果蝇的寿命长16%,但使用大剂量的锂将会缩短果蝇的寿命。

科学家说,这项研究结果令人鼓舞,也许能够最终导致延长人类寿命或保持生命健康的新药问世。

Thumbnail image of Figure 1. Opens large image

据悉,锂目前在精神病学中已有应用,可用来帮助调整情绪变化,但使用高剂量的锂存在产生严重副作用的风险。

报道指出,科学家目前还不完全了解锂对大脑作用的机理,但对果蝇来说,锂似乎可以通过阻断GSK3/NRF2途径来延长寿命。

报道称,领导这项研究工作的英国伦敦大学学院健康老年研究所教授帕特里奇说:“我们所看到的低剂量锂对果蝇产生的作用非常令人鼓舞,下一步工作将针对更复杂的动物的GSK-3物质,以便最终研发出能进行人类实验的药物。”

部分资助这项研究的慈善机构“英国帕金森氏症防治协会”研究联络主管贝尔说,这是有关老化的一个重要发现,“也许有一天我们能够干预老化过程”。

她还说,这项研究不仅可能让老年生命更健康,也可能为治疗,甚至是防止诸如帕金森氏症等老年疾病提供重要的条件。

原始出处:

Jorge Iván Castillo-Quan, Li Li, Kerri J. Kinghorn, Dobril K. Ivanov, Luke S. Tain, Cathy Slack, Fiona Kerr, Tobias Nespital, and others. Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis.  Cell Reports DOI: http://dx.doi.org/10.1016/j.celrep.2016.03.041 
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    2016-12-10 DEXTER3150
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time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77536, encodeId=6241e7536dd, content=吃一点锂电池能不能延长寿命呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Apr 12 19:20:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480426, encodeId=1a5e1480426ce, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Tue Apr 12 08:49:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77394, encodeId=8f07e7394bb, content=值得学习挺有借鉴意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/67C748B7AD5CD73B9F90B9B8653DF627/40, createdBy=22141705243, createdName=QQ113e4867, createdTime=Mon Apr 11 09:44:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77392, encodeId=1e30e739295, content=什么软件做的图, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Mon Apr 11 09:16:00 CST 2016, time=2016-04-11, status=1, ipAttribution=)]
    2016-04-14 维他命
  5. 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time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77536, encodeId=6241e7536dd, content=吃一点锂电池能不能延长寿命呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Apr 12 19:20:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480426, encodeId=1a5e1480426ce, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Tue Apr 12 08:49:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77394, encodeId=8f07e7394bb, content=值得学习挺有借鉴意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/67C748B7AD5CD73B9F90B9B8653DF627/40, createdBy=22141705243, createdName=QQ113e4867, createdTime=Mon Apr 11 09:44:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77392, encodeId=1e30e739295, content=什么软件做的图, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Mon Apr 11 09:16:00 CST 2016, time=2016-04-11, status=1, ipAttribution=)]
    2016-04-14 李继凯

    高大上啊

    0

  6. 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time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77536, encodeId=6241e7536dd, content=吃一点锂电池能不能延长寿命呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Apr 12 19:20:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480426, encodeId=1a5e1480426ce, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Tue Apr 12 08:49:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77394, encodeId=8f07e7394bb, content=值得学习挺有借鉴意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/67C748B7AD5CD73B9F90B9B8653DF627/40, createdBy=22141705243, createdName=QQ113e4867, createdTime=Mon Apr 11 09:44:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77392, encodeId=1e30e739295, content=什么软件做的图, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Mon Apr 11 09:16:00 CST 2016, time=2016-04-11, status=1, ipAttribution=)]
    2016-04-14 李继凯

    值得学习

    0

  7. 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time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77536, encodeId=6241e7536dd, content=吃一点锂电池能不能延长寿命呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Apr 12 19:20:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480426, encodeId=1a5e1480426ce, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Tue Apr 12 08:49:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77394, encodeId=8f07e7394bb, content=值得学习挺有借鉴意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/67C748B7AD5CD73B9F90B9B8653DF627/40, createdBy=22141705243, createdName=QQ113e4867, createdTime=Mon Apr 11 09:44:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77392, encodeId=1e30e739295, content=什么软件做的图, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Mon Apr 11 09:16:00 CST 2016, time=2016-04-11, status=1, ipAttribution=)]
    2016-04-12 lovetcm

    吃一点锂电池能不能延长寿命呀!

    0

  8. 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  9. 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    2016-04-11 QQ113e4867

    值得学习挺有借鉴意义的

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  10. 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    2016-04-11 hekzn

    什么软件做的图

    0

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