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BMJ：警惕锂盐药物的急性肾损害

2014-11-17 MedSci译 MedSci原创

锂双相情感障碍急性肾损害肾小球滤过率
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根据东安格利亚的大学的（UEA）一项新的研究。双相情感障碍患者并且正在接受含锂药物治疗的人群的有高度的急性肾脏损害风险，需要严格仔细的监测。[pdf free] 锂在双相情感障碍的治疗中一向有着中流砥柱的地位，但是在锂盐使用和肾功能损耗的关系上还存在一定争议。人们对一次以上的高水平锂暴露对肾脏功能的具体影响还知之甚少。诺福克研究团队为此就多次锂暴露的影响进行探究。这项研究明确了短期高水平的锂

根据东安格利亚的大学的（UEA）一项新的研究。双相情感障碍患者并且正在接受含锂药物治疗的人群的有高度的急性肾脏损害风险，需要严格仔细的监测。[pdf free]


锂在双相情感障碍的治疗中一向有着中流砥柱的地位，但是在锂盐使用和肾功能损耗的关系上还存在一定争议。人们对一次以上的高水平锂暴露对肾脏功能的具体影响还知之甚少。诺福克研究团队为此就多次锂暴露的影响进行探究。这项研究明确了短期高水平的锂暴露和潜在损害肾脏之间的联系。

为了明确不同浓度锂对肾小球滤过率估算值（eGFR）在不同时间段（3个月，6个月，1年）的影响程度，东安格利亚的大学药学院、诺维奇医学院药学院和诺福克萨福克NHS的药剂师们共同着手对过去十年来在Norfolk SystemTDM database注册的接受锂盐治疗的699名患者进行回顾性分析。

研究者按照锂的暴露浓度将样本人群分为四组;低于0.8mmol/L（reference group）；0.81–1.0 mmol/L (group 2) ；1.01–1.2 mmol/L (group 3) 和 1.21–2.0 mmol/L (group 4)。 评估以下三个时间段：少于三个月、6个月 (±3个月)、12个月(±3个月)里服药人群的 eGFR和基线eGFR相比的变化。



结果显示和对照组相比，第三、第四组的eGFR在3个月内有明显的下降 (p=0.047，p=0.040)，在暴露后的第6个月第四组仍显示eGFR 的下降，尽管下降不显著(p=0.298)。

研究者指出这些结果首次表明了和低浓度锂暴露（<0.8mmol/L）相比，一次高浓度的锂暴露（>1.0mmol/L）和接下来3个月的eGFR显著下降相关。并且浓度越高，损害越重，肾脏是否可以完全恢复受损的肾脏不为人知，在上述浓度水平的持续多次锂暴露又对肾脏有有着怎样具体的影响亦不为人知。

主持这项研究的东安格利亚的大学Emma Kirkham 博士对记者说：“这些研究结果告诉我们血清锂浓度的检测应该至少每3个月一次，这和现行的UK指南相一致。直到持续暴露对肾脏损害的机制和修复情况被彻底充分阐明之前，这些定期的检测不可避免。”

原始出处：

Kirkham E, Skinner J, Anderson T, Bazire S, Twigg MJ, Desborough JA. One lithium level >1.0 mmol/L causes an acute decline in eGFR: findings from a retrospective analysis of a monitoring database BMJ Open. 2014 Nov 7;4(11):e006020. doi:10.1136/bmjopen-2014-006020.[pdf free]


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  1. [GetPortalCommentsPageByObjectIdResponse(id=1721722, encodeId=9b9a1e2172293, content=<a href='/topic/show?id=34439669547' target=_blank style='color:#2F92EE;'>#锂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96695, encryptionId=34439669547, topicName=锂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7a933073777, createdName=DEXTER3150, createdTime=Thu Mar 12 20:20:00 CST 2015, time=2015-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33965, encodeId=ad31339652f, content=我们好像不太用锂盐, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Sat Aug 01 12:12:00 CST 2015, time=2015-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20286, encodeId=b1732028649, content=AKI对心衰临床治疗意义重大，但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:29:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754605, encodeId=0eab1e5460570, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Tue Dec 23 09:20:00 CST 2014, time=2014-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13162, encodeId=845313162eb, content=双相情感障碍患者并且正在接受含锂药物治疗的人群的有高度的急性肾脏损害风险，需要严格仔细的监测。这些研究结果告诉我们血清锂浓度的检测应该至少每3个月一次，这和现行的UK指南相一致, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13163, encodeId=4497131634a, content=锂在双相情感障碍的治疗中一向有着中流砥柱的地位，但是在锂盐使用和肾功能损耗的关系上还存在一定争议。这项研究明确了短期高水平的锂暴露和潜在损害肾脏之间的联系, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847629, encodeId=3737184e6299f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Feb 08 08:20:00 CST 2015, time=2015-02-08, status=1, ipAttribution=)]
    2015-03-12 DEXTER3150

    #锂#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1721722, encodeId=9b9a1e2172293, content=<a href='/topic/show?id=34439669547' target=_blank style='color:#2F92EE;'>#锂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96695, encryptionId=34439669547, topicName=锂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7a933073777, createdName=DEXTER3150, createdTime=Thu Mar 12 20:20:00 CST 2015, time=2015-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33965, encodeId=ad31339652f, content=我们好像不太用锂盐, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Sat Aug 01 12:12:00 CST 2015, time=2015-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20286, encodeId=b1732028649, content=AKI对心衰临床治疗意义重大，但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:29:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754605, encodeId=0eab1e5460570, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Tue Dec 23 09:20:00 CST 2014, time=2014-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13162, encodeId=845313162eb, content=双相情感障碍患者并且正在接受含锂药物治疗的人群的有高度的急性肾脏损害风险，需要严格仔细的监测。这些研究结果告诉我们血清锂浓度的检测应该至少每3个月一次，这和现行的UK指南相一致, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13163, encodeId=4497131634a, content=锂在双相情感障碍的治疗中一向有着中流砥柱的地位，但是在锂盐使用和肾功能损耗的关系上还存在一定争议。这项研究明确了短期高水平的锂暴露和潜在损害肾脏之间的联系, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847629, encodeId=3737184e6299f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Feb 08 08:20:00 CST 2015, time=2015-02-08, status=1, ipAttribution=)]
    2015-08-01 sundong

    我们好像不太用锂盐

    0

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    2015-04-11 x35042875

    AKI对心衰临床治疗意义重大，但依然需要研究检验其适用性

    0

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    2014-12-23 lq0313

    #肾损害#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1721722, encodeId=9b9a1e2172293, content=<a href='/topic/show?id=34439669547' target=_blank style='color:#2F92EE;'>#锂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96695, encryptionId=34439669547, topicName=锂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7a933073777, createdName=DEXTER3150, createdTime=Thu Mar 12 20:20:00 CST 2015, time=2015-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33965, encodeId=ad31339652f, content=我们好像不太用锂盐, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Sat Aug 01 12:12:00 CST 2015, time=2015-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20286, encodeId=b1732028649, content=AKI对心衰临床治疗意义重大，但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:29:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754605, encodeId=0eab1e5460570, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Tue Dec 23 09:20:00 CST 2014, time=2014-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13162, encodeId=845313162eb, content=双相情感障碍患者并且正在接受含锂药物治疗的人群的有高度的急性肾脏损害风险，需要严格仔细的监测。这些研究结果告诉我们血清锂浓度的检测应该至少每3个月一次，这和现行的UK指南相一致, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13163, encodeId=4497131634a, content=锂在双相情感障碍的治疗中一向有着中流砥柱的地位，但是在锂盐使用和肾功能损耗的关系上还存在一定争议。这项研究明确了短期高水平的锂暴露和潜在损害肾脏之间的联系, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847629, encodeId=3737184e6299f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Feb 08 08:20:00 CST 2015, time=2015-02-08, status=1, ipAttribution=)]
    2014-12-16 cbp

    双相情感障碍患者并且正在接受含锂药物治疗的人群的有高度的急性肾脏损害风险，需要严格仔细的监测。这些研究结果告诉我们血清锂浓度的检测应该至少每3个月一次，这和现行的UK指南相一致

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1721722, encodeId=9b9a1e2172293, content=<a href='/topic/show?id=34439669547' target=_blank style='color:#2F92EE;'>#锂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96695, encryptionId=34439669547, topicName=锂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7a933073777, createdName=DEXTER3150, createdTime=Thu Mar 12 20:20:00 CST 2015, time=2015-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33965, encodeId=ad31339652f, content=我们好像不太用锂盐, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Sat Aug 01 12:12:00 CST 2015, time=2015-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20286, encodeId=b1732028649, content=AKI对心衰临床治疗意义重大，但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:29:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754605, encodeId=0eab1e5460570, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Tue Dec 23 09:20:00 CST 2014, time=2014-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13162, encodeId=845313162eb, content=双相情感障碍患者并且正在接受含锂药物治疗的人群的有高度的急性肾脏损害风险，需要严格仔细的监测。这些研究结果告诉我们血清锂浓度的检测应该至少每3个月一次，这和现行的UK指南相一致, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13163, encodeId=4497131634a, content=锂在双相情感障碍的治疗中一向有着中流砥柱的地位，但是在锂盐使用和肾功能损耗的关系上还存在一定争议。这项研究明确了短期高水平的锂暴露和潜在损害肾脏之间的联系, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847629, encodeId=3737184e6299f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Feb 08 08:20:00 CST 2015, time=2015-02-08, status=1, ipAttribution=)]
    2014-12-16 cbp

    锂在双相情感障碍的治疗中一向有着中流砥柱的地位，但是在锂盐使用和肾功能损耗的关系上还存在一定争议。这项研究明确了短期高水平的锂暴露和潜在损害肾脏之间的联系

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1721722, encodeId=9b9a1e2172293, content=<a href='/topic/show?id=34439669547' target=_blank style='color:#2F92EE;'>#锂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96695, encryptionId=34439669547, topicName=锂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7a933073777, createdName=DEXTER3150, createdTime=Thu Mar 12 20:20:00 CST 2015, time=2015-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33965, encodeId=ad31339652f, content=我们好像不太用锂盐, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Sat Aug 01 12:12:00 CST 2015, time=2015-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20286, encodeId=b1732028649, content=AKI对心衰临床治疗意义重大，但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:29:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754605, encodeId=0eab1e5460570, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Tue Dec 23 09:20:00 CST 2014, time=2014-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13162, encodeId=845313162eb, content=双相情感障碍患者并且正在接受含锂药物治疗的人群的有高度的急性肾脏损害风险，需要严格仔细的监测。这些研究结果告诉我们血清锂浓度的检测应该至少每3个月一次，这和现行的UK指南相一致, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13163, encodeId=4497131634a, content=锂在双相情感障碍的治疗中一向有着中流砥柱的地位，但是在锂盐使用和肾功能损耗的关系上还存在一定争议。这项研究明确了短期高水平的锂暴露和潜在损害肾脏之间的联系, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Tue Dec 16 16:56:00 CST 2014, time=2014-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847629, encodeId=3737184e6299f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Feb 08 08:20:00 CST 2015, time=2015-02-08, status=1, ipAttribution=)]
    2015-02-08 gaoxiaoe

    #BMJ#

    0