Hypertension:2型糖尿病患者降糖降压 强强联合反折寿损福

2018-08-14 徐钰琦 环球医学

研究人员进行了一项试验,旨在考察强化降压对接受标准但非强化血糖控制的2型糖尿病患者的益处,评估强化血压(BP)治疗是否对预防心血管疾病有益,包括2型糖尿病患者的心衰。研究结果2018年8月发表于《Hypertension》上。

强化降压与标准降压一直本身就存在争议,孰好孰坏不能“一棒子打死”。强化或非强化降糖糖尿病患者,临床医生该不该强化降压处理。如何选择治疗方案,着实令人头疼。

为此,研究人员进行了一项试验,旨在考察强化降压对接受标准但非强化血糖控制的2型糖尿病患者的益处,评估强化血压(BP)治疗是否对预防血管疾病有益,包括2型糖尿病患者的心衰。研究结果2018年8月发表于《Hypertension》上。

使用ACCORD BP试验(控制糖尿病血压血管风险的行动)数据,使用Cox比例风险模型计算心血管事件风险比和95%置信区间,来比较接受标准(n=2362)或强化血糖控制(n=2371)的患者中,第一次出现心血管事件的时间。

总体平均随访4.5年,528名患者发生心血管事件。

在接受标准血糖控制的患者中,强化BP治疗组心血管事件风险显着低于标准BP治疗组;在接受强化血糖控制的患者中,组间无显着差异。

BP治疗策略与血糖控制之间存在显着相互作用。强化BP治疗组,接受标准血糖控制的患者的卒中风险显着降低,接受强化血糖控制的患者中则没有。在强化血糖控制患者中,接受强化BP控制的患者的全因死亡率高于接受标准BP治疗的患者,但并不显着。

在ACCORD BP参与者中,仅在标准血糖控制且无额外风险因素者中观察到强化BP治疗的益处。

本研究证实,对于标准血糖控制的患者,强化BP治疗是最佳选择,可降低高危2型糖尿病患者的心血管事件风险(包括心衰)。

对于强化降糖患者,强化BP治疗,卒中风险没有变化,反而可能升高全因死亡率。因此,标准降压或是这部分患者好的选择。

原始出处:

Tsujimoto T and Kajio H. Benefits of Intensive Blood Pressure Treatment in Patients With Type 2 Diabetes Mellitus Receiving Standard but Not Intensive Glycemic Control. Hypertension. 2018 Aug;72(2):323-330. doi: 10.1161/HYPERTENSIONAHA.118.11408.

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    2019-06-09 feather89
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    2018-09-17 大爰

    学习了谢谢分享!!

    0

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    2018-08-14 misszhang

    谢谢MedSci提供最新的资讯

    0

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心血管疾病是2型糖尿病(T2DM)的主要风险之一。既往研究报道了红细胞(RBCs)在心功能调节中的重要作用,T2DM患者的RBC功能有所改变,且精氨酸酶的活性有所增高。本研究的目的旨在证明T2DM患者的红细胞可以通过上调精氨酸酶水平引起内皮功能不全。本研究对T2DM患者和年龄匹配的对照的红细胞进行了分离,并与大鼠主动脉或非糖尿病患者的乳腺内动脉血管共培养。分析结果显示,T2DM患者的红细胞精氨酸酶

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研究认为,相比于其他口服II型糖尿病药物,钠-葡萄糖共转运体2抑制剂的下肢病变截肢风险显著增加

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非酒精性脂肪性肝病(NAFLD),在一些国家是最为常见的肝脏疾病。鉴于NAFLD危害巨大,有必要了解各种降糖药对脂肪肝的影响,对糖尿病合并脂肪肝患者选择更加合适的药物。

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某男性患者,67岁。既往有糖尿病史20余年,长期口服二甲双胍、阿卡波糖等药物治疗,血糖控制尚可。1周前,患者受凉后出现腹泻、水样便,伴恶心、纳差,1天前家人发现患者言行反常,遂来急诊。