期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 80 ()
Starting with our previously reported work, a novel series of 3,4-dihydro-2H-[1,4]oxazino[2,3-f]quinazolin-derivatives were designed, synthesized and ......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 80 ()
A series of novel 2-fluoro ketolide antibiotics with 11,12-quinoylalkyl side chains derived from telithromycin and cethromycin were designed and synth......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 81 ()
BCR-ABL1 kinase is a key driver of the pathophysiology of chronic myeloid leukemia (CML). Current treatments need to broaden the chemical diversity of......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 84 ()
A library of new pyrimidine analogs was designed and synthesized of these, compound K10 bearing a 1,4-benzodioxane moiety and 3,4,5-trimethoxyphenyl g......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 91 ()
An increasing number of neurodegenerative diseases seem to be associated with protein misfolding that often leads to misfolded protein aggregates with......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 91 ()
The clinical use of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in the treatment of non-small cell lung cancer was limited......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 92 ()
Nicotinamide phosphoribosyltransferase (NAMPT) has emerged as a promising target for cancer therapy due to its strong correlation with nicotinamide ad......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 96 ()
The poor water solubility of traditional activatable organic molecular probes usually limits their detection ability in physiological environment. In ......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 96 ()
In recent years, PD-1/PD-L1 checkpoint blockade immunotherapy with remarkable efficacy has set off a heat wave. The expression level of PD-L1, which p......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 96 ()
Camptothecin (CPT) and its derivatives are potent candidates for cancer treatment. However, the clinical ap-plications are largely restricted by non-s......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 79 ()
Smallpox was eradicated >40 years ago but it is not a reason to forget forever about orthopoxviruses pathogenic to humans. Though in 1980 the decis......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 80 ()
Natural products have been the most important sources of chemically diverse raw materials that have inspired pharmaceutical discoveries over the past ......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 80 ()
Mutation of FLT3 protein kinase is often associated with deregulated cell proliferation in acute myeloid leukemia and the inhibition of this kinase is......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 80 ()
Lankamycin, a macrolide antibiotic produced by Streptomyces rochei 7434AN4, exhibits a moderate antimicrobial activity and acts as a synergistic pair ......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 81 ()
A synthesis of 2 '-fluoro and 2 '-methoxy N6-methyladenosine phosphoramidites and their successful incorpora-tion into oligonucleotides is reported. 2......
